Literature DB >> 7888295

Inhibition of caffeine metabolism by ciprofloxacin in children with cystic fibrosis as measured by the caffeine breath test.

A C Parker1, T Preston, D Heaf, N R Kitteringham, I Choonara.   

Abstract

The caffeine breath test was carried out in six children with cystic fibrosis, before and during a course of ciprofloxacin. There was a significant decrease in the 2 h cumulative labelled CO2 exhaled during ciprofloxacin treatment, mean difference (s.d.) -5.2(3.3)%, P < 0.02. The results suggest an inhibition of 3-N-demethylation of caffeine (CYP1A2 enzyme activity) by ciprofloxacin. Ciprofloxacin may cause significant drug interactions in children with cystic fibrosis. The caffeine breath test can be used to study drug interactions involving CYP1A2 in children.

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Year:  1994        PMID： 7888295      PMCID： PMC1364921          DOI： 10.1111/j.1365-2125.1994.tb04399.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  12 in total

1.  Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Authors:  M A Butler; M Iwasaki; F P Guengerich; F F Kadlubar
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

2.  A clinically significant interaction between ciprofloxacin and theophylline.

Authors:  A H Thomson; G D Thomson; M Hepburn; B Whiting
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

3.  Clinical diagnosis with the stable isotope 13C in CO2 breath tests: methodology and fundamental considerations.

Authors:  D A Schoeller; J F Schneider; N W Solomons; J B Watkins; P D Klein
Journal:  J Lab Clin Med       Date:  1977-09

4.  The effect of age, gender, and sexual maturation on the caffeine breath test.

Authors:  G H Lambert; D A Schoeller; A N Kotake; C Flores; D Hay
Journal:  Dev Pharmacol Ther       Date:  1986

5.  Individual and combined effects of cimetidine and ciprofloxacin on theophylline metabolism in male nonsmokers.

Authors:  C M Loi; B M Parker; B J Cusack; R Vestal
Journal:  Br J Clin Pharmacol       Date:  1993-09       Impact factor: 4.335

Review 6.  The CO2 breath tests as monitors of the cytochrome P450 dependent mixed function monooxygenase system.

Authors:  G H Lambert; A N Kotake; D Schoeller
Journal:  Prog Clin Biol Res       Date:  1983

7.  Maturation of caffeine N-demethylation in infancy: a study using the 13CO2 breath test.

Authors:  G Pons; J C Blais; E Rey; M Plissonnier; M O Richard; O Carrier; P d'Athis; C Moran; J Badoual; G Olive
Journal:  Pediatr Res       Date:  1988-06       Impact factor: 3.756

8.  Rapid sample throughput for biomedical stable isotope tracer studies.

Authors:  T Preston; D C McMillan
Journal:  Biomed Environ Mass Spectrom       Date:  1988-10

9.  Effect of growth hormone therapy in growth hormone-deficient children on cytochrome P-450-dependent 3-N-demethylation of caffeine as measured by the caffeine 13CO2 breath test.

Authors:  L L Levitsky; D A Schoeller; G H Lambert; D V Edidin
Journal:  Dev Pharmacol Ther       Date:  1989

10.  4-quinolones inhibit biotransformation of caffeine.

Authors:  S Harder; A H Staib; C Beer; A Papenburg; W Stille; P M Shah
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953
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  9 in total

Review 1.  Drug trials in children: problems and the way forward.

Authors:  S Conroy; J McIntyre; I Choonara; T Stephenson
Journal:  Br J Clin Pharmacol       Date:  2000-02       Impact factor: 4.335

2.  Enhanced drug metabolism in young children with cystic fibrosis.

Authors:  A C Parker; P Pritchard; T Preston; R L Smyth; I Choonara
Journal:  Arch Dis Child       Date:  1997-09       Impact factor: 3.791

3.  Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test.

Authors:  A C Parker; P Pritchard; T Preston; I Choonara
Journal:  Br J Clin Pharmacol       Date:  1998-02       Impact factor: 4.335

Review 4.  Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2.

Authors:  Shu-Feng Zhou; Li-Ping Yang; Zhi-Wei Zhou; Ya-He Liu; Eli Chan
Journal:  AAPS J       Date:  2009-07-10       Impact factor: 4.009

Review 5.  Ciprofloxacin. An updated review of its pharmacology, therapeutic efficacy and tolerability.

Authors:  R Davis; A Markham; J A Balfour
Journal:  Drugs       Date:  1996-06       Impact factor: 9.546

6.  Lack of a significant change in caffeine metabolism in underweight children as determined by the caffeine breath test.

Authors:  K A Oshikoya; H Sammons; K Smith; I Choonara
Journal:  Arch Dis Child       Date:  2015-04-20       Impact factor: 3.791

7.  Significance of the 13C-caffeine breath test for patients with cirrhosis.

Authors:  Dimitrios Konstantinou; Ekaterini Margariti; Emilia Hadziyannis; Dimitrios Pectasides; George V Papatheodoridis
Journal:  Ann Gastroenterol       Date:  2014

8.  Pharmacokinetic drug interactions of antimicrobial drugs: a systematic review on oxazolidinones, rifamycines, macrolides, fluoroquinolones, and Beta-lactams.

Authors:  Mathieu S Bolhuis; Prashant N Panday; Arianna D Pranger; Jos G W Kosterink; Jan-Willem C Alffenaar
Journal:  Pharmaceutics       Date:  2011-11-18       Impact factor: 6.321

Review 9.  Paediatric clinical pharmacology in the UK.

Authors:  Imti Choonara; Helen Sammons
Journal:  Arch Dis Child       Date:  2014-09-08       Impact factor: 3.791
  9 in total

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