AIMS: Carbamazepine is a known enzyme inducer. The aim of this study was to determine whether carbamazepine induces the metabolism of caffeine in children. METHODS: Children due to receive carbamazepine for epilepsy were recruited into the study. The caffeine breath test was carried out prior to the administration of carbamazepine and after a minimum of 2-3 weeks therapy. Five children were studied and they received 200-600 mg carbamazepine daily. RESULTS: The mean values of the 2 h cumulative labelled carbon dioxide were 3.47% before and 7.65% during carbamazepine. There was a significant increase in the percentage labelled caffeine exhaled as carbon dioxide during the administration of carbamazepine (Student's paired t-test, P < 0.05). CONCLUSIONS: The results suggest that carbamazepine induces the metabolism of caffeine by the CYP1A2 pathway in the children studied.
AIMS: Carbamazepine is a known enzyme inducer. The aim of this study was to determine whether carbamazepine induces the metabolism of caffeine in children. METHODS:Children due to receive carbamazepine for epilepsy were recruited into the study. The caffeine breath test was carried out prior to the administration of carbamazepine and after a minimum of 2-3 weeks therapy. Five children were studied and they received 200-600 mg carbamazepine daily. RESULTS: The mean values of the 2 h cumulative labelled carbon dioxide were 3.47% before and 7.65% during carbamazepine. There was a significant increase in the percentage labelled caffeine exhaled as carbon dioxide during the administration of carbamazepine (Student's paired t-test, P < 0.05). CONCLUSIONS: The results suggest that carbamazepine induces the metabolism of caffeine by the CYP1A2 pathway in the children studied.
Authors: L Pichard; I Fabre; G Fabre; J Domergue; B Saint Aubert; G Mourad; P Maurel Journal: Drug Metab Dispos Date: 1990 Sep-Oct Impact factor: 3.922
Authors: S Kondo; T Fukasawa; N Yasui-Furukori; T Aoshima; A Suzuki; Y Inoue; T Tateishi; K Otani Journal: Eur J Clin Pharmacol Date: 2005-03-18 Impact factor: 2.953
Authors: Edward F Fitzgerald; Syni-An Hwang; George Lambert; Marta Gomez; Alice Tarbell Journal: Environ Health Perspect Date: 2005-03 Impact factor: 9.031