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Literature DB >> 3443151

A clinically significant interaction between ciprofloxacin and theophylline.

A H Thomson¹, G D Thomson, M Hepburn, B Whiting.

Abstract

We report a case of theophylline toxicity following the co-administration of ciprofloxacin. Total theophylline clearance fell from 2.3 l.h-1 to 0.8 l.h-1 when ciprofloxacin was added to the treatment regimen and returned to 2.1 l.h-1 after ciprofloxacin was discontinued.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1987 PMID： 3443151 DOI： 10.1007/BF00637645

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

5 in total

1. Quinolones and raised plasma concentrations of theophylline.

Authors: F P Maesen; J P Teengs; C Baur; B I Davies
Journal: Lancet Date: 1984-09-01 Impact factor: 79.321

2. OPT: a package of computer programs for parameter optimisation in clinical pharmacokinetics.

Authors: A W Kelman; B Whiting; S M Bryson
Journal: Br J Clin Pharmacol Date: 1982-08 Impact factor: 4.335

3. The influence of quinolone derivatives on theophylline clearance.

Authors: W J Wijnands; T B Vree; C L van Herwaarden
Journal: Br J Clin Pharmacol Date: 1986-12 Impact factor: 4.335

4. Treatment of respiratory tract infections with ciprofloxacin.

Authors: S Raoof; C Wollschlager; F Khan
Journal: J Antimicrob Chemother Date: 1986-11 Impact factor: 5.790

5. Effect of multiple dose oral ciprofloxacin on the pharmacokinetics of theophylline and indocyanine green.

Authors: D E Nix; J M DeVito; M A Whitbread; J J Schentag
Journal: J Antimicrob Chemother Date: 1987-02 Impact factor: 5.790

5 in total

16 in total

Review 1. Pharmacokinetic interactions between theophylline and other medication (Part II).

Authors: R A Upton
Journal: Clin Pharmacokinet Date: 1991-02 Impact factor: 6.447

2. Danger of interaction between ciprofloxacin and theophylline.

Authors: J L Bem; R D Mann
Journal: Br Med J (Clin Res Ed) Date: 1988-04-16

3. Probable fatal interaction between ciprofloxacin and theophylline.

Authors: R Holden
Journal: BMJ Date: 1988-11-19

4. Ciprofloxacin-induced theophylline toxicity: a population-based study.

Authors: Tony Antoniou; Tara Gomes; Muhammad M Mamdani; David N Juurlink
Journal: Eur J Clin Pharmacol Date: 2011-01-14 Impact factor: 2.953

5. Lack of interaction between lomefloxacin and caffeine in normal volunteers.

Authors: D P Healy; J R Schoenle; J Stotka; R E Polk
Journal: Antimicrob Agents Chemother Date: 1991-04 Impact factor: 5.191

6. Effect of lomefloxacin on theophylline pharmacokinetics.

Authors: D E Nix; A Norman; J J Schentag
Journal: Antimicrob Agents Chemother Date: 1989-07 Impact factor: 5.191

7. Influence of subject age on the inhibition of oxidative metabolism by ciprofloxacin.

Authors: N M Waite; M J Rybak; D J Krakovsky; J D Steinberg; L H Warbasse; D J Edwards
Journal: Antimicrob Agents Chemother Date: 1991-01 Impact factor: 5.191

8. The effect of ciprofloxacin on theophylline pharmacokinetics in healthy subjects.

Authors: K T Batty; T M Davis; K F Ilett; L J Dusci; S R Langton
Journal: Br J Clin Pharmacol Date: 1995-03 Impact factor: 4.335

Review 9. Clinical pharmacokinetics of ciprofloxacin.

Authors: K Vance-Bryan; D R Guay; J C Rotschafer
Journal: Clin Pharmacokinet Date: 1990-12 Impact factor: 6.447

10. Effects of enoxacin on renal and metabolic clearance of theophylline in rats.

Authors: M Nadai; T Hasegawa; T Kuzuya; I Muraoka; K Takagi; H Yoshizumi
Journal: Antimicrob Agents Chemother Date: 1990-09 Impact factor: 5.191