Literature DB >> 786633

Indolmycin inhibits prokaryotic tryptophanyl-tRNA ligase.

R G Werner, L F Thorpe, W Reuter, K H Nierhaus.   

Abstract

Indolmycin specifically prevents the formation of tryptophanyl-tRNA in a prokaryotic system in vitro using Escherichia coli enzymes. However, the drug has little effect in an eukaryotic system in vitro (rat liver enzymes). Analysis of the type of inhibition revealed that indolmycin competes with tryptophan as a pure competitive inhibitor of prokaryotic tryptophanyl-tRNA ligase.

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Year:  1976        PMID： 786633     DOI： 10.1111/j.1432-1033.1976.tb10758.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  27 in total

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Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

2.  Enrichment of Auxotrophic Mutants in Streptomyces griseus.

Authors:  R G Werner; A L Demain
Journal:  Appl Environ Microbiol       Date:  1980-09       Impact factor: 4.792

3.  Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.

Authors:  Xiang-Lei Yang; Francella J Otero; Karla L Ewalt; Jianming Liu; Manal A Swairjo; Caroline Köhrer; Uttam L RajBhandary; Robert J Skene; Duncan E McRee; Paul Schimmel
Journal:  EMBO J       Date:  2006-05-25       Impact factor: 11.598

4.  Characterization of an inducible, antibiotic-resistant aminoacyl-tRNA synthetase gene in Streptomyces coelicolor.

Authors:  James J Vecchione; Jason K Sello
Journal:  J Bacteriol       Date:  2008-07-11       Impact factor: 3.490

5.  High-frequency transposition for determining antibacterial mode of action.

Authors:  Hao Wang; David Claveau; John P Vaillancourt; Terry Roemer; Timothy C Meredith
Journal:  Nat Chem Biol       Date:  2011-09-04       Impact factor: 15.040

Review 6.  Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics.

Authors:  Christopher S Francklyn; Patrick Mullen
Journal:  J Biol Chem       Date:  2019-01-22       Impact factor: 5.157

7.  Ribosomal function and its inhibition by antibiotics in prokaryotes.

Authors:  K H Nierhaus; H G Wittmann
Journal:  Naturwissenschaften       Date:  1980-05

8.  In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.

Authors:  Yi-Ling Du; Lona M Alkhalaf; Katherine S Ryan
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-17       Impact factor: 11.205

9.  Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design.

Authors:  Minyun Zhou; Xianchi Dong; Ning Shen; Chen Zhong; Jianping Ding
Journal:  Nucleic Acids Res       Date:  2010-01-31       Impact factor: 16.971

10.  Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Escherichia coli by pseudomonic acid.

Authors:  J Hughes; G Mellows
Journal:  Biochem J       Date:  1978-10-15       Impact factor: 3.857
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