Literature DB >> 18621902

Characterization of an inducible, antibiotic-resistant aminoacyl-tRNA synthetase gene in Streptomyces coelicolor.

James J Vecchione1, Jason K Sello.   

Abstract

Streptomyces coelicolor has two genes encoding tryptophanyl-tRNA synthetases, one of which (trpRS1) is resistant to and transcriptionally activated by indolmycin. We found that this gene also confers resistance to chuangxinmycin (another antibiotic that inhibits bacterial tryptophanyl-tRNA synthetases) and that its transcription is not absolutely dependent on either antibiotic.

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Year:  2008        PMID： 18621902      PMCID： PMC2546804          DOI： 10.1128/JB.00737-08

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  22 in total

1.  Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori.

Authors:  B Björkholm; M Sjölund; P G Falk; O G Berg; L Engstrand; D I Andersson
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-20       Impact factor: 11.205

2.  The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.

Authors:  Murray J Brown; Paul S Carter; Ashley S Fenwick; Andrew P Fosberry; Dieter W Hamprecht; Martin J Hibbs; Richard L Jarvest; Lucy Mensah; Peter H Milner; Peter J O'Hanlon; Andrew J Pope; Christine M Richardson; Andrew West; David R Witty
Journal:  Bioorg Med Chem Lett       Date:  2002-11-04       Impact factor: 2.823

3.  The stringent response in Streptomyces coelicolor A3(2).

Authors:  E Strauch; E Takano; H A Baylis; M J Bibb
Journal:  Mol Microbiol       Date:  1991-02       Impact factor: 3.501

Review 4.  How antibiotic-producing organisms avoid suicide.

Authors:  E Cundliffe
Journal:  Annu Rev Microbiol       Date:  1989       Impact factor: 15.500

5.  Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).

Authors:  S D Bentley; K F Chater; A-M Cerdeño-Tárraga; G L Challis; N R Thomson; K D James; D E Harris; M A Quail; H Kieser; D Harper; A Bateman; S Brown; G Chandra; C W Chen; M Collins; A Cronin; A Fraser; A Goble; J Hidalgo; T Hornsby; S Howarth; C-H Huang; T Kieser; L Larke; L Murphy; K Oliver; S O'Neil; E Rabbinowitsch; M-A Rajandream; K Rutherford; S Rutter; K Seeger; D Saunders; S Sharp; R Squares; S Squares; K Taylor; T Warren; A Wietzorrek; J Woodward; B G Barrell; J Parkhill; D A Hopwood
Journal:  Nature       Date:  2002-05-09       Impact factor: 49.962

Review 6.  Inactivation of antibiotics and the dissemination of resistance genes.

Authors:  J Davies
Journal:  Science       Date:  1994-04-15       Impact factor: 47.728

7.  Identity of streptomycete producing antibiotic PA155A.

Authors:  J B Routien
Journal:  J Bacteriol       Date:  1966-04       Impact factor: 3.490

8.  Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections.

Authors:  Julian G Hurdle; Alex J O'Neill; Ian Chopra
Journal:  J Antimicrob Chemother       Date:  2004-07-08       Impact factor: 5.790

9.  Indolmycin inhibits prokaryotic tryptophanyl-tRNA ligase.

Authors:  R G Werner; L F Thorpe; W Reuter; K H Nierhaus
Journal:  Eur J Biochem       Date:  1976-09

10.  Indolmycin-mediated inhibition and stimulation of transcription at the trp promoter of Escherichia coli.

Authors:  G Bogosian; P V Haydock; R L Somerville
Journal:  J Bacteriol       Date:  1983-02       Impact factor: 3.490
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  5 in total

1.  Regulation of an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene via ribosome-mediated transcriptional attenuation.

Authors:  James J Vecchione; Jason K Sello
Journal:  J Bacteriol       Date:  2010-05-07       Impact factor: 3.490

Review 2.  Biosynthesis and Chemical Synthesis of Albomycin Nucleoside Antibiotics.

Authors:  Meiyan Wang; Yuxin Zhang; Lanxin Lv; Dekun Kong; Guoqing Niu
Journal:  Antibiotics (Basel)       Date:  2022-03-24

3.  Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase.

Authors:  Corey L Compton; Karl R Schmitz; Robert T Sauer; Jason K Sello
Journal:  ACS Chem Biol       Date:  2013-10-04       Impact factor: 5.100

4.  Two distinct major facilitator superfamily drug efflux pumps mediate chloramphenicol resistance in Streptomyces coelicolor.

Authors:  James J Vecchione; Blair Alexander; Jason K Sello
Journal:  Antimicrob Agents Chemother       Date:  2009-08-17       Impact factor: 5.191

5.  A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.

Authors:  James J Vecchione; Jason K Sello
Journal:  Antimicrob Agents Chemother       Date:  2009-06-22       Impact factor: 5.191
  5 in total

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