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Literature DB >> 7791533

Side-chain oxysterol regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.

Abstract

Side-chain oxysterols are known to be potent inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase, a key regulatory enzyme in the biosynthesis of sterols. Structural variations in the side-chain oxysterols influence enzyme inhibition. Under certain conditions, biological systems have been induced to produce side-chain oxysterols, adding support to the hypothesis that oxysterols may be natural regulators of sterol biosynthesis in the intact cell. Specific inhibition of sterol biosynthesis is of interest as it may prove useful in the prevention or reversal of various cardiovascular disease states, as well as in the control of normal and abnormal cell growth.

Entities: Chemical Disease Gene

Mesh：

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Year: 1995 PMID： 7791533 DOI： 10.1007/bf02537828

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

44 in total

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Journal: J Biol Chem Date: 1985-11-25 Impact factor: 5.157

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Journal: J Biol Chem Date: 1988-06-25 Impact factor: 5.157

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Authors: A A Kandutsch; E B Thompson
Journal: J Biol Chem Date: 1980-11-25 Impact factor: 5.157

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Authors: F R Taylor; S E Saucier; E P Shown; E J Parish; A A Kandutsch
Journal: J Biol Chem Date: 1984-10-25 Impact factor: 5.157

4 in total