Literature DB >> 1967820

Regulation of the mevalonate pathway.

J L Goldstein1, M S Brown.   

Abstract

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

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Year:  1990        PMID： 1967820     DOI： 10.1038/343425a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  1270 in total

1.  Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites.

Authors:  S Xiong; S S Chirala; S J Wakil
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-11       Impact factor: 11.205

2.  Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.

Authors:  A Montalvetti; J Peña-Díaz; R Hurtado; L M Ruiz-Pérez; D González-Pacanowska
Journal:  Biochem J       Date:  2000-07-01       Impact factor: 3.857

3.  The prenylation status of a novel plant calmodulin directs plasma membrane or nuclear localization of the protein.

Authors:  M Rodríguez-Concepción; S Yalovsky; M Zik; H Fromm; W Gruissem
Journal:  EMBO J       Date:  1999-04-01       Impact factor: 11.598

Review 4.  Monogenic dyslipidemias: window on determinants of plasma lipoprotein metabolism.

Authors:  R A Hegele
Journal:  Am J Hum Genet       Date:  2001-10-26       Impact factor: 11.025

5.  Some nutritional factors influencing mevinolin production by Aspergillus terreus strain.

Authors:  A A Shindia
Journal:  Folia Microbiol (Praha)       Date:  2001       Impact factor: 2.099

6.  Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry.

Authors:  D K Han; J Eng; H Zhou; R Aebersold
Journal:  Nat Biotechnol       Date:  2001-10       Impact factor: 54.908

7.  Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I.

Authors:  G Martin; H Duez; C Blanquart; V Berezowski; P Poulain; J C Fruchart; J Najib-Fruchart; C Glineur; B Staels
Journal:  J Clin Invest       Date:  2001-06       Impact factor: 14.808

8.  In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation.

Authors:  R G Gardner; A G Shearer; R Y Hampton
Journal:  Mol Cell Biol       Date:  2001-07       Impact factor: 4.272

Review 9.  Inflammation and lipid-lowering treatment.

Authors:  C M Ballantyne; Y Abe
Journal:  Curr Cardiol Rep       Date:  1999-09       Impact factor: 2.931

10.  Effect of ring-substituted oxysterols on the phase behavior of dipalmitoylphosphatidylcholine membranes.

Authors:  Md Arif Kamal; V A Raghunathan
Journal:  Eur Biophys J       Date:  2012-06-06       Impact factor: 1.733
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