Remote functionalization of the steroid side-chain.

By using classical methods of organic synthesis, the introduction of chemical modifications into the saturated side-chains of steroids usually requires a multistep synthesis to construct new side-chains to be added to the steroid nucleus. In order to circumvent these earlier methods, new procedures have been developed to directly introduce functionality onto the steroid side-chain to produce useful products. These initial products may also provide an entry toward the further modification of the side-chain to produce steroids which could previously be obtained only with great difficulty.