Literature DB >> 775440

Role of modified nucleosides in tRNA: effect of modification of the 2-thiouridine derivative located at the 5'-end of the anticodon of yeast transfer RNA Lys2.

G C Sen, H P Ghosh.   

Abstract

Yeast tRNA Lys2 codes preferentially for AAA and contains a 2-thiouridine derivative (U) at the 5'-position of the anticodon. Removal of the 2-thio group from U by treatment with CNBr did not affect the amino acid accepting activity of the modified tRNA Lys2. CNBr treated tRNA Lys2 was active in protein synthesis but with a much reduced efficiency. Although the modified tRNA Lys2 was recognized by elongation factor (EF) T, the EFT dependent binding to ribosomes to tRNA Lys2 (CNBr) was markedly decreased.

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Year:  1976        PMID： 775440      PMCID： PMC342923          DOI： 10.1093/nar/3.3.523

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  21 in total

1.  5-methyl-2-thiouridine: A new sulfur-containing minor constituent from rat liver glutamic acid and lysine tRNAs.

Authors:  F Kimura-Harada; M Saneyoshi; S Nishimura
Journal:  FEBS Lett       Date:  1971-04-02       Impact factor: 4.124

2.  Coding properties of isoaccepting lysine transfer RNA species from baker's yeast.

Authors:  G C Sen; H P Ghosh
Journal:  Biochim Biophys Acta       Date:  1973-04-21

3.  Biological function of 2-thiouridine in Escherichia coli glutamic acid transfer ribonucleic acid.

Authors:  P F Agris; D Söll; T Seno
Journal:  Biochemistry       Date:  1973-10-23       Impact factor: 3.162

4.  Oligonucleotide composition of a yeast lysine transfer ribonucleic acid.

Authors:  J T Madison; S J Boguslawski; G H Teetor
Journal:  Biochemistry       Date:  1974-01-29       Impact factor: 3.162

5.  Role of modified nucleosides in transfer ribonucleic acid. Effect of removal of the modified base adjacent to 3' end of the anticodon in codon-anticodon interaction.

Authors:  K Ghosh; H P Ghosh
Journal:  J Biol Chem       Date:  1972-06-10       Impact factor: 5.157

Review 6.  Minor components in transfer RNA: their characterization, location, and function.

Authors:  S Nishimura
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1972

7.  Involvement of the anticodon region of Escherichia coli tRNAGln and tRNAGlu in the specific interaction with cognate aminoacyl-tRNA synthetase. Alteration of the 2-thiouridine derivatives located in the anticodon of the tRNAs by BrCN or sulfur deprivation.

Authors:  T Seno; P F Agris; D Söll
Journal:  Biochim Biophys Acta       Date:  1974-05-31

8.  A fast and sensitive method for the analysis of modified nucleosides in tRNA.

Authors:  G C Sen; H P Ghosh
Journal:  Anal Biochem       Date:  1974-04       Impact factor: 3.365

9.  T4 transfer RNAs: codon recognition and translational properties.

Authors:  N H Scherberg; S B Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  1972-05       Impact factor: 11.205

10.  Structural studies on a yeast glutamic acid tRNA specific to GAA codon.

Authors:  M Yoshida; K Takeishi; T Ukita
Journal:  Biochim Biophys Acta       Date:  1971-01-01
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  11 in total

1.  The iscS gene is essential for the biosynthesis of 2-selenouridine in tRNA and the selenocysteine-containing formate dehydrogenase H.

Authors:  Hisaaki Mihara; Shin-ichiro Kato; Gerard M Lacourciere; Thressa C Stadtman; Robert A J D Kennedy; Tatsuo Kurihara; Umechiyo Tokumoto; Yasuhiro Takahashi; Nobuyoshi Esaki
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-07       Impact factor: 11.205

Review 2.  Urm1 at the crossroad of modifications. 'Protein Modifications: Beyond the Usual Suspects' Review Series.

Authors:  Patrick G A Pedrioli; Sebastian Leidel; Kay Hofmann
Journal:  EMBO Rep       Date:  2008-12       Impact factor: 8.807

3.  tRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding.

Authors:  Vanessa Anissa Nathalie Rezgui; Kshitiz Tyagi; Namit Ranjan; Andrey L Konevega; Joerg Mittelstaet; Marina V Rodnina; Matthias Peter; Patrick G A Pedrioli
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-08       Impact factor: 11.205

Review 4.  Thionucleosides in transfer ribonucleic acid: diversity, structure, biosynthesis, and function.

Authors:  P Ajitkumar; J D Cherayil
Journal:  Microbiol Rev       Date:  1988-03

5.  5-(carboxymethylaminomethyl)-2-thiouridine, a new modified nucleoside found at the first letter position of the anticodon.

Authors:  Y Yamada; K Murao; H Ishikura
Journal:  Nucleic Acids Res       Date:  1981-04-24       Impact factor: 16.971

Review 6.  The dual role of ubiquitin-like protein Urm1 as a protein modifier and sulfur carrier.

Authors:  Fengbin Wang; Meiruo Liu; Rui Qiu; Chaoneng Ji
Journal:  Protein Cell       Date:  2011-09-09       Impact factor: 14.870

7.  Single atom modification (O-->S) of tRNA confers ribosome binding.

Authors:  S S Ashraf; E Sochacka; R Cain; R Guenther; A Malkiewicz; P F Agris
Journal:  RNA       Date:  1999-02       Impact factor: 4.942

8.  1H NMR studies on the conformational characteristics of 2-thiopyrimidine nucleotides found in transfer RNAs.

Authors:  S Yokoyama; Z Yamaizumi; S Nishimura; T Miyazawa
Journal:  Nucleic Acids Res       Date:  1979-06-11       Impact factor: 16.971

9.  IscS functions as a primary sulfur-donating enzyme by interacting specifically with MoeB and MoaD in the biosynthesis of molybdopterin in Escherichia coli.

Authors:  Wanjiao Zhang; Alexander Urban; Hisaaki Mihara; Silke Leimkühler; Tatsuo Kurihara; Nobuyoshi Esaki
Journal:  J Biol Chem       Date:  2009-11-29       Impact factor: 5.157

10.  Antisuppressor mutation in Escherichia coli defective in biosynthesis of 5-methylaminomethyl-2-thiouridine.

Authors:  M A Sullivan; J F Cannon; F H Webb; R M Bock
Journal:  J Bacteriol       Date:  1985-01       Impact factor: 3.490
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