OBJECTIVE:CSF levels of inositol have been reported to be lower than normal in depressed subjects. The authors administered inositol to depressed patients in a double-blind, controlled trial. METHOD: Under double-blind conditions, 12 g/day of inositol (N = 13) or placebo (N = 15) was administered to depressed patients for 4 weeks. RESULTS: The overall improvement in scores on the Hamilton Depression Rating Scale was significantly greater for inositol than for placebo at week 4. No changes were noted in hematology or in kidney or liver function. CONCLUSIONS: This may be the first use of the precursor strategy for a second messenger rather than a neurotransmitter in treating depression. Although inositol had a significant antidepressant effect in this study, replication is crucial.
RCT Entities:
OBJECTIVE:CSF levels of inositol have been reported to be lower than normal in depressed subjects. The authors administered inositol to depressedpatients in a double-blind, controlled trial. METHOD: Under double-blind conditions, 12 g/day of inositol (N = 13) or placebo (N = 15) was administered to depressedpatients for 4 weeks. RESULTS: The overall improvement in scores on the Hamilton Depression Rating Scale was significantly greater for inositol than for placebo at week 4. No changes were noted in hematology or in kidney or liver function. CONCLUSIONS: This may be the first use of the precursor strategy for a second messenger rather than a neurotransmitter in treating depression. Although inositol had a significant antidepressant effect in this study, replication is crucial.
Authors: Yaoyang Zhang; Michaela D Filiou; Stefan Reckow; Philipp Gormanns; Giuseppina Maccarrone; Melanie S Kessler; Elisabeth Frank; Boris Hambsch; Florian Holsboer; Rainer Landgraf; Christoph W Turck Journal: Mol Cell Proteomics Date: 2011-08-23 Impact factor: 5.911
Authors: Nick C Patel; Melissa P DelBello; Kim M Cecil; Caleb M Adler; Holly S Bryan; Kevin E Stanford; Stephen M Strakowski Journal: Biol Psychiatry Date: 2006-11-01 Impact factor: 13.382
Authors: R N Parthasarathy; J Lakshmanan; M Thangavel; R S Seelan; J I Stagner; A J Janckila; R E Vadnal; M F Casanova; L K Parthasarathy Journal: Mol Cell Biochem Date: 2013-03-16 Impact factor: 3.396