BACKGROUND: The neurochemical effects of lithium in adolescents with bipolar disorder largely are unknown. This study used proton magnetic resonance spectroscopy (1H MRS) to identify the in vivo effects of lithium on myo-inositol (mI) concentrations in adolescent bipolar depression. METHODS: Twenty-eight adolescents (12-18 years old) with bipolar I disorder, current episode depressed, received open-label lithium 30 mg/kg, adjusted to achieve serum levels of 1.0-1.2 mEq/L. The mI concentrations in the medial as well as the left and right lateral prefrontal cortices were measured at baseline, day 7, and day 42 of treatment. Changes in mI concentrations over time were analyzed. RESULTS: Significant main effects of time were observed for mI concentrations in the medial (p = .03) and right lateral (p = .05) prefrontal cortices. Baseline concentrations of mI were not significantly different from day 7 or day 42 concentrations. However, mI concentrations on day 42 were significantly higher than those on day 7 (p = .02) in both regions. CONCLUSIONS: This study demonstrates that prefrontal mI concentrations do not significantly change from baseline after acute and chronic lithium treatment in adolescents with bipolar depression. Further investigation of the effect of lithium on mI is warranted to better understand possible mechanisms by which lithium exerts antidepressant activity.
BACKGROUND: The neurochemical effects of lithium in adolescents with bipolar disorder largely are unknown. This study used proton magnetic resonance spectroscopy (1H MRS) to identify the in vivo effects of lithium on myo-inositol (mI) concentrations in adolescent bipolar depression. METHODS: Twenty-eight adolescents (12-18 years old) with bipolar I disorder, current episode depressed, received open-label lithium 30 mg/kg, adjusted to achieve serum levels of 1.0-1.2 mEq/L. The mI concentrations in the medial as well as the left and right lateral prefrontal cortices were measured at baseline, day 7, and day 42 of treatment. Changes in mI concentrations over time were analyzed. RESULTS: Significant main effects of time were observed for mI concentrations in the medial (p = .03) and right lateral (p = .05) prefrontal cortices. Baseline concentrations of mI were not significantly different from day 7 or day 42 concentrations. However, mI concentrations on day 42 were significantly higher than those on day 7 (p = .02) in both regions. CONCLUSIONS: This study demonstrates that prefrontal mI concentrations do not significantly change from baseline after acute and chronic lithium treatment in adolescents with bipolar depression. Further investigation of the effect of lithium on mI is warranted to better understand possible mechanisms by which lithium exerts antidepressant activity.
Authors: Robinder K Bhangoo; Catherine H Lowe; Frances S Myers; Julia Treland; Justin Curran; Kenneth E Towbin; Ellen Leibenluft Journal: J Child Adolesc Psychopharmacol Date: 2003 Impact factor: 2.576
Authors: Latha K Parthasarathy; Ratnam S Seelan; Mark A Wilson; Robert E Vadnal; Ranga N Parthasarathy Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2003-02 Impact factor: 5.067
Authors: Stephen R Dager; Seth D Friedman; Aimee Parow; Christina Demopulos; Andrew L Stoll; In Kyoon Lyoo; David L Dunner; Perry F Renshaw Journal: Arch Gen Psychiatry Date: 2004-05
Authors: Pablo Davanzo; Kenneth Yue; M Albert Thomas; Thomas Belin; Jim Mintz; T N Venkatraman; Eliana Santoro; Sarah Barnett; James McCracken Journal: Am J Psychiatry Date: 2003-08 Impact factor: 18.112
Authors: Manpreet K Singh; Booil Jo; Nancy E Adleman; Meghan Howe; Layla Bararpour; Ryan G Kelley; Daniel Spielman; Kiki D Chang Journal: Psychiatry Res Date: 2013-09-09 Impact factor: 3.222
Authors: Xian-Feng Shi; Douglas G Kondo; Young-Hoon Sung; Tracy L Hellem; Kristen K Fiedler; Eun-Kee Jeong; Rebekah S Huber; Perry F Renshaw Journal: Bipolar Disord Date: 2012-07-20 Impact factor: 6.744
Authors: Daniel P Dickstein; Kenneth E Towbin; Jan Willem Van Der Veen; Brendan A Rich; Melissa A Brotman; Lisa Knopf; Laura Onelio; Daniel S Pine; Ellen Leibenluft Journal: J Child Adolesc Psychopharmacol Date: 2009-02 Impact factor: 2.576
Authors: D G Kondo; T L Hellem; X-F Shi; Y H Sung; A P Prescot; T S Kim; R S Huber; L N Forrest; P F Renshaw Journal: AJNR Am J Neuroradiol Date: 2014-02-20 Impact factor: 3.825
Authors: Nick C Patel; Kim M Cecil; Stephen M Strakowski; Caleb M Adler; Melissa P DelBello Journal: J Child Adolesc Psychopharmacol Date: 2008-12 Impact factor: 2.576
Authors: Samantha M Bitter; Wade A Weber; Wen-Jang Chu; Caleb M Adler; James C Eliassen; Stephen M Strakowski; Melissa P DelBello Journal: J Dual Diagn Date: 2014
Authors: Brent P Forester; Chelsea T Finn; Yosef A Berlow; Megan Wardrop; Perry F Renshaw; Constance M Moore Journal: Bipolar Disord Date: 2008-09 Impact factor: 6.744