Literature DB >> 9203091

Inositol has behavioral effects with adaptation after chronic administration.

H Cohen1, M Kotler, Z Kaplan, M A Matar, O Kofman, R H Belmaker.   

Abstract

Inositol is a simple dietary polyol that serves as a precursor in important second messenger systems. Inositol in pharmacological doses has been reported recently to be therapeutic in depression, panic disorder and obsessive compulsive disorder. We hereby report effects of inositol on the elevated plus maze model of anxiety. These results should allow development of new inositol analogs that could expand psychoactive drug development possibilities via second messenger manipulation.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9203091     DOI： 10.1007/BF01273190

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  26 in total

1.  Clomipramine and initial worsening in panic disorder: beyond the 'jitteriness syndrome'.

Authors:  R T Ramos; V Gentil; C Gorenstein
Journal:  J Psychopharmacol       Date:  1993-01       Impact factor: 4.153

Review 2.  Second messenger systems and psychoactive drug action: focus on the phosphoinositide system and lithium.

Authors:  J M Baraban; P F Worley; S H Snyder
Journal:  Am J Psychiatry       Date:  1989-10       Impact factor: 18.112

3.  An animal model for measuring behavioral responses to anxiogenic and anxiolytic manipulations.

Authors:  J C Stout; J M Weiss
Journal:  Pharmacol Biochem Behav       Date:  1994-03       Impact factor: 3.533

4.  Purification of phosphatidylinositol synthetase from rat brain by CDP-diacylglycerol affinity chromatography and properties of the purified enzyme.

Authors:  A Ghalayini; J Eichberg
Journal:  J Neurochem       Date:  1985-01       Impact factor: 5.372

5.  Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures.

Authors:  O Kofman; W R Sherman; V Katz; R H Belmaker
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

6.  The effect of peripheral inositol injection on rat motor activity models of depression.

Authors:  O Kofman; Y Bersudsky; I Vinnitsky; C Alpert; R H Belmaker
Journal:  Isr J Med Sci       Date:  1993-09

7.  Effect of extracellular myo-inositol on surfactant phospholipid synthesis in the fetal rabbit lung.

Authors:  M Hallman
Journal:  Biochim Biophys Acta       Date:  1984-08-15

8.  Normalization of Na(+)-K(+)-ATPase activity in isolated membrane fraction from sciatic nerves of streptozocin-induced diabetic rats by dietary myo-inositol supplementation in vivo or protein kinase C agonists in vitro.

Authors:  J Kim; H Kyriazi; D A Greene
Journal:  Diabetes       Date:  1991-05       Impact factor: 9.461

9.  High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithium.

Authors:  G Agam; Y Shapiro; Y Bersudsky; O Kofman; R H Belmaker
Journal:  Pharmacol Biochem Behav       Date:  1994-10       Impact factor: 3.533

10.  Myo-inositol reduces serotonin (5-HT2) receptor induced homologous and heterologous desensitization.

Authors:  S Rahman; R S Neuman
Journal:  Brain Res       Date:  1993-12-24       Impact factor: 3.252
View more
  2 in total

1.  Epi-inositol and inositol depletion: two new treatment approaches in affective disorder.

Authors:  Y Bersudsky; H Einat; Z Stahl; R H Belmaker
Journal:  Curr Psychiatry Rep       Date:  1999-12       Impact factor: 5.285

2.  Behavioral metabolomics analysis identifies novel neurochemical signatures in methamphetamine sensitization.

Authors:  D E Adkins; J L McClay; S A Vunck; A M Batman; R E Vann; S L Clark; R P Souza; J J Crowley; P F Sullivan; E J C G van den Oord; P M Beardsley
Journal:  Genes Brain Behav       Date:  2013-09-30       Impact factor: 3.449
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.