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Literature DB >> 7688718

Inhibition of the mitochondrial calcium uniporter by antibodies against a 40-kDa glycoproteinT.

N E Saris¹, T V Sirota, I Virtanen, K Niva, T Penttilä, L P Dolgachova, G D Mironova.

Abstract

Polyclonal rabbit antibodies against a Ca(2+)-binding mitochondrial glycoprotein were found to inhibit the uniporter-mediated transport of Ca2+ in mitoplasts prepared from rat liver mitochondria. Spermine, a modulator of the uniporter, decreased the inhibition. This glycoprotein of M(r) 40,000, isolated from beef heart mitochondria and earlier shown to form Ca(2+)-conducting channels in black-lipid membranes, thus is a good candidate for being a component of the uniporter. Antibody-IgG was found to specifically bind to mitochondria in human fibroblasts.

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Year: 1993 PMID： 7688718 DOI： 10.1007/bf00762591

Source DB: PubMed Journal: J Bioenerg Biomembr ISSN： 0145-479X Impact factor: 2.945

24 in total

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12 in total

Review 1. Mitochondrial Ca²⁺ homeostasis: mechanism, role, and tissue specificities.

Authors: Paola Pizzo; Ilaria Drago; Riccardo Filadi; Tullio Pozzan
Journal: Pflugers Arch Date: 2012-06-16 Impact factor: 3.657

Review 2. Mitochondrial ion channels.

Authors: Brian O'Rourke
Journal: Annu Rev Physiol Date: 2007 Impact factor: 19.318

Review 3. The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications.

Authors: Saverio Marchi; Paolo Pinton
Journal: J Physiol Date: 2013-12-23 Impact factor: 5.182

Review 4. Electrophysiology of the inner mitochondrial membrane.

Authors: M Zoratti; I Szabó
Journal: J Bioenerg Biomembr Date: 1994-10 Impact factor: 2.945

Review 5. After half a century mitochondrial calcium in- and efflux machineries reveal themselves.

Authors: Ilaria Drago; Paola Pizzo; Tullio Pozzan
Journal: EMBO J Date: 2011-09-20 Impact factor: 11.598

6. Identification of a 20-kDa protein with calcium uptake transport activity. Reconstitution in a membrane model.

Authors: C Zazueta; F Massò; A Paez; C Bravo; A Vega; L Montaño; M Vázquez; J Ramírez; E Chávez
Journal: J Bioenerg Biomembr Date: 1994-10 Impact factor: 2.945

7. Purification of the channel component of the mitochondrial calcium uniporter and its reconstitution into planar lipid bilayers.

Authors: G D Mironova; M Baumann; O Kolomytkin; Z Krasichkova; A Berdimuratov; T Sirota; I Virtanen; N E Saris
Journal: J Bioenerg Biomembr Date: 1994-04 Impact factor: 2.945