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Literature DB >> 7534761

Electrophysiology of the inner mitochondrial membrane.

Abstract

The application of electrophysiological techniques to mitochondrial membranes has allowed the observation and partial characterization of several ion channels, including an ATP-sensitive K(+)-selective one, a high-conductance "megachannel", a 107 pS anionic channel and three others studied at alkaline pH's. A reliable correlation with the results of non-electrophysiological studies has been obtained so far only for the first two cases. Activities presumed to be associated with the Ca2+ uniporter and with the adenine nucleotide translocator, as well as the presence of various other conductances have also been reported. The review summarizes the main properties of these pores and their possible relationship to permeation pathways identified in biochemical studies.

Entities: Chemical

Mesh：

Substances：

Year: 1994 PMID： 7534761 DOI： 10.1007/bf00762739

Source DB: PubMed Journal: J Bioenerg Biomembr ISSN： 0145-479X Impact factor: 2.945

100 in total

1. Osmotic swelling of heart mitochondria in acetate and chloride salts. Evidence for two pathways for cation uptake.

Authors: G P Brierley; M Jurkowitz; D W Jung
Journal: Arch Biochem Biophys Date: 1978-09 Impact factor: 4.013

2. Purification and patch clamp analysis of a 40-pS channel from rat liver mitochondria.

Authors: R Paliwal; G Costa; J J Diwan
Journal: Biochemistry Date: 1992-03-03 Impact factor: 3.162

3. A mitochondrial protein fraction catalyzing transport of the K+ analog T1+.

Authors: J J Diwan; R Paliwal; E Kaftan; R Bawa
Journal: FEBS Lett Date: 1990-10-29 Impact factor: 4.124

4. An anion-conducting pore in the mitochondrial inner membrane [proceedings].

Authors: M J Selwyn; A P Dawson; D V Fulton
Journal: Biochem Soc Trans Date: 1979-02 Impact factor: 5.407

5. New substrates and competitive inhibitors of the Cl- translocating pathway of the uncoupling protein of brown adipose tissue mitochondria.

Authors: P Jezek; K D Garlid
Journal: J Biol Chem Date: 1990-11-05 Impact factor: 5.157

6. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors: O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal: Pflugers Arch Date: 1981-08 Impact factor: 3.657

7. Inhibition of the mitochondrial calcium uniporter by antibodies against a 40-kDa glycoproteinT.

Authors: N E Saris; T V Sirota; I Virtanen; K Niva; T Penttilä; L P Dolgachova; G D Mironova
Journal: J Bioenerg Biomembr Date: 1993-06 Impact factor: 2.945

8. Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate. Evidence for two distinct swelling mechanisms.

Authors: A M Davidson; A P Halestrap
Journal: Biochem J Date: 1990-05-15 Impact factor: 3.857

9. Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

Authors: P Bernardi
Journal: J Biol Chem Date: 1992-05-05 Impact factor: 5.157

10. Crucial role of sulfhydryl groups in the mitochondrial inner membrane structure.

Authors: K Lê-Quôc; D Lê-Quôc
Journal: J Biol Chem Date: 1985-06-25 Impact factor: 5.157

34 in total

Review 1. Pathophysiological and protective roles of mitochondrial ion channels.

Authors: B O'Rourke
Journal: J Physiol Date: 2000-11-15 Impact factor: 5.182

Review 2. The local control of cytosolic Ca2+ as a propagator of CNS communication--integration of mitochondrial transport mechanisms and cellular responses.

Authors: P B Simpson
Journal: J Bioenerg Biomembr Date: 2000-02 Impact factor: 2.945

Review 7. Mitochondrial ion channels.

Authors: Brian O'Rourke
Journal: Annu Rev Physiol Date: 2007 Impact factor: 19.318

Electrophysiology of the inner mitochondrial membrane.

1. Osmotic swelling of heart mitochondria in acetate and chloride salts. Evidence for two pathways for cation uptake.

2. Purification and patch clamp analysis of a 40-pS channel from rat liver mitochondria.

3. A mitochondrial protein fraction catalyzing transport of the K+ analog T1+.

4. An anion-conducting pore in the mitochondrial inner membrane [proceedings].

5. New substrates and competitive inhibitors of the Cl- translocating pathway of the uncoupling protein of brown adipose tissue mitochondria.

6. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

7. Inhibition of the mitochondrial calcium uniporter by antibodies against a 40-kDa glycoproteinT.

8. Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate. Evidence for two distinct swelling mechanisms.

9. Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

10. Crucial role of sulfhydryl groups in the mitochondrial inner membrane structure.

Review 1. Pathophysiological and protective roles of mitochondrial ion channels.

Review 2. The local control of cytosolic Ca2+ as a propagator of CNS communication--integration of mitochondrial transport mechanisms and cellular responses.

Review 3. Signaling and cellular mechanisms in cardiac protection by ischemic and pharmacological preconditioning.

Review 4. Interplay between mitochondria and cellular calcium signalling.

5. Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6.

Review 6. Mitochondrial ion channels: gatekeepers of life and death.

Review 7. Mitochondrial ion channels.

Review 8. Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms.

Review 9. Anion channels of the inner membrane of mammalian and yeast mitochondria.

Review 10. Mitochondrial Ca²⁺ concentrations in live cells: quantification methods and discrepancies.

Review 1. Pathophysiological and protective roles of mitochondrial ion channels.

Review 2. The local control of cytosolic Ca2+ as a propagator of CNS communication--integration of mitochondrial transport mechanisms and cellular responses.

Review 3. Signaling and cellular mechanisms in cardiac protection by ischemic and pharmacological preconditioning.

Review 4. Interplay between mitochondria and cellular calcium signalling.

Review 6. Mitochondrial ion channels: gatekeepers of life and death.

Review 7. Mitochondrial ion channels.

Review 8. Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms.

Review 9. Anion channels of the inner membrane of mammalian and yeast mitochondria.

Review 10. Mitochondrial Ca2+ concentrations in live cells: quantification methods and discrepancies.

Review 10. Mitochondrial Ca²⁺ concentrations in live cells: quantification methods and discrepancies.