Literature DB >> 7675106

Transcription complex stability and chromatin dynamics in vivo.

M Wijgerde1, F Grosveld, P Fraser.   

Abstract

Distant regulatory sequences affect transcription through long-range chromatin interactions. Visualization of transcriptional activity of genes that compete for distant elements, using the globin locus as a model, has revealed the dynamics of chromatin interactions in vivo. Multiple genes appear to be transcribed alternately rather than at the same time to generate several messenger RNAs in one cell. The regulator may stably complex with one gene at a time and switch back and forth between genes in a flip-flop mechanism.

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Year:  1995        PMID： 7675106     DOI： 10.1038/377209a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  155 in total

1.  Structural and functional cross-talk between a distant enhancer and the epsilon-globin gene promoter shows interdependence of the two elements in chromatin.

Authors:  J C McDowell; A Dean
Journal:  Mol Cell Biol       Date:  1999-11       Impact factor: 4.272

2.  Role of NF-Y in in vivo regulation of the gamma-globin gene.

Authors:  Z Duan; G Stamatoyannopoulos; Q Li
Journal:  Mol Cell Biol       Date:  2001-05       Impact factor: 4.272

3.  Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly.

Authors:  K M Leach; K Nightingale; K Igarashi; P P Levings; J D Engel; P B Becker; J Bungert
Journal:  Mol Cell Biol       Date:  2001-04       Impact factor: 4.272

4.  Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells.

Authors:  S Luikenhuis; A Wutz; R Jaenisch
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

5.  Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations.

Authors:  T B Kepler; T C Elston
Journal:  Biophys J       Date:  2001-12       Impact factor: 4.033

6.  The role of the -50 region of the human gamma-globin gene in switching.

Authors:  M S Ristaldi; D Drabek; J Gribnau; D Poddie; N Yannoutsous; A Cao; F Grosveld; A M Imam
Journal:  EMBO J       Date:  2001-09-17       Impact factor: 11.598

7.  Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4.

Authors:  W Zhou; D R Clouston; X Wang; L Cerruti; J M Cunningham; S M Jane
Journal:  Mol Cell Biol       Date:  2000-10       Impact factor: 4.272

8.  Inefficient processing impairs release of RNA from the site of transcription.

Authors:  N Custódio; M Carmo-Fonseca; F Geraghty; H S Pereira; F Grosveld; M Antoniou
Journal:  EMBO J       Date:  1999-05-17       Impact factor: 11.598

Review 9.  Locus control regions.

Authors:  Qiliang Li; Kenneth R Peterson; Xiangdong Fang; George Stamatoyannopoulos
Journal:  Blood       Date:  2002-11-01       Impact factor: 22.113

10.  The developmental activation of the chicken lysozyme locus in transgenic mice requires the interaction of a subset of enhancer elements with the promoter.

Authors:  M C Huber; U Jägle; G Krüger; C Bonifer
Journal:  Nucleic Acids Res       Date:  1997-08-01       Impact factor: 16.971
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