Literature DB >> 7606365

Mapping of gene loci in the Q13-Q15 region of chromosome 12.

E L Mitchell1, G R White, M F Santibanez-Koref, J M Varley, J Heighway.   

Abstract

The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13-q15 region of chromosome 12. Using fluorescence in situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3-14.1, CDK4 to 12q14 and MDM2 to 12q14.3-q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.

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Year:  1995        PMID： 7606365     DOI： 10.1007/BF00713052

Source DB:  PubMed          Journal:  Chromosome Res        ISSN： 0967-3849            Impact factor:   5.239


  12 in total

1.  A 3.5 genome equivalent multi access YAC library: construction, characterisation, screening and storage.

Authors:  R Anand; J H Riley; R Butler; J C Smith; A F Markham
Journal:  Nucleic Acids Res       Date:  1990-04-25       Impact factor: 16.971

2.  In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3-14.1.

Authors:  K Arheden; M Rønne; N Mandahl; S Heim; K W Kinzler; B Vogelstein; F Mitelman
Journal:  Hum Genet       Date:  1989-04       Impact factor: 4.132

3.  Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?

Authors:  F P Li; J F Fraumeni
Journal:  Ann Intern Med       Date:  1969-10       Impact factor: 25.391

4.  Determination of the gene order of the three loci CD2, NGFB, and NRAS at human chromosome band 1p13 and refinement of their localisation at the subband level by fluorescence in situ hybridisation.

Authors:  E L Mitchell; D Jones; G R White; J M Varley; M F Santibanez Koref
Journal:  Cytogenet Cell Genet       Date:  1995

5.  A transcribed polymorphism and sub-localisation of MDM2.

Authors:  J Heighway; E L Mitchell; D Jones; G R White; M F Santibáñez Koref
Journal:  Hum Genet       Date:  1994-05       Impact factor: 4.132

6.  Amplification of a gene encoding a p53-associated protein in human sarcomas.

Authors:  J D Oliner; K W Kinzler; P S Meltzer; D L George; B Vogelstein
Journal:  Nature       Date:  1992-07-02       Impact factor: 49.962

7.  Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes.

Authors:  D J Demetrick; H Zhang; D H Beach
Journal:  Cytogenet Cell Genet       Date:  1994

8.  Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.

Authors:  Z A Khatib; H Matsushime; M Valentine; D N Shapiro; C J Sherr; A T Look
Journal:  Cancer Res       Date:  1993-11-15       Impact factor: 12.701

9.  p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

Authors:  F S Leach; T Tokino; P Meltzer; M Burrell; J D Oliner; S Smith; D E Hill; D Sidransky; K W Kinzler; B Vogelstein
Journal:  Cancer Res       Date:  1993-05-15       Impact factor: 12.701

10.  Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families.

Authors:  J M Birch; A L Hartley; K J Tricker; J Prosser; A Condie; A M Kelsey; M Harris; P H Jones; A Binchy; D Crowther
Journal:  Cancer Res       Date:  1994-03-01       Impact factor: 12.701
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  3 in total

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Journal:  J Mol Med (Berl)       Date:  2005-04-09       Impact factor: 4.599

2.  Recurrent gains of 1q, 8 and 12 in the Ewing family of tumours by comparative genomic hybridization.

Authors:  G Armengol; M Tarkkanen; M Virolainen; A Forus; J Valle; T Böhling; S Asko-Seljavaara; C Blomqvist; I Elomaa; E Karaharju; A H Kivioja; M A Siimes; E Tukiainen; M R Caballín; O Myklebost; S Knuutila
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

3.  The Role of p16 and MDM2 Gene Polymorphisms in Prolactinoma: MDM2 Gene Polymorphisms May Be Associated with Tumor Shrinkage.

Authors:  Seda Turgut; Muzaffer Ilhan; Saime Turan; Ozcan Karaman; Ilhan Yaylim; Ozlem Kucukhuseyin; Ertugrul Tasan
Journal:  In Vivo       Date:  2017 May-Jun       Impact factor: 2.155
  3 in total

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