Literature DB >> 7789166

Determination of the gene order of the three loci CD2, NGFB, and NRAS at human chromosome band 1p13 and refinement of their localisation at the subband level by fluorescence in situ hybridisation.

E L Mitchell1, D Jones, G R White, J M Varley, M F Santibanez Koref.   

Abstract

The three loci NRAS, NGFB, and CD2 map to human chromosome band 1p13. Using fluorescence in situ hybridisation (FISH) to simultaneously DAPI-banded metaphase chromosomes, we have further refined the localisation of these three genes to specific subbands. NRAS localises to subband 1p13.2 and CD2 and NGFB to 1p13.1. Also, with the use of multicolour FISH, we have determined the order and orientation of the three loci in relation to the centromere. The order is cen-CD2-NGFB-NRAS.

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Year:  1995        PMID： 7789166     DOI： 10.1159/000134028

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  7 in total

1.  Physical localisation of the breakpoints of a constitutional translocation t(5;6)(q21;q21) in a child with bilateral Wilms' tumour.

Authors:  P R Hoban; R L Cowen; E L Mitchell; D G Evans; M Kelly; P J Howard; J Heighway
Journal:  J Med Genet       Date:  1997-04       Impact factor: 6.318

2.  Analysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21.

Authors:  T Sherratt; C Morelli; J M Boyle; C J Harrison
Journal:  Chromosome Res       Date:  1997-04       Impact factor: 5.239

3.  Mapping of gene loci in the Q13-Q15 region of chromosome 12.

Authors:  E L Mitchell; G R White; M F Santibanez-Koref; J M Varley; J Heighway
Journal:  Chromosome Res       Date:  1995-06       Impact factor: 5.239

Review 4.  Activated ras. Yet another player in melanoma?

Authors:  M Herlyn; K Satyamoorthy
Journal:  Am J Pathol       Date:  1996-09       Impact factor: 4.307

5.  Identification of recurrent regions of chromosome loss and gain in vestibular schwannomas using comparative genomic hybridisation.

Authors:  C Warren; L A James; R T Ramsden; A Wallace; M E Baser; J M Varley; D G Evans
Journal:  J Med Genet       Date:  2003-11       Impact factor: 6.318

6.  Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization.

Authors:  L A James; A M Kelsey; J M Birch; J M Varley
Journal:  Br J Cancer       Date:  1999-09       Impact factor: 7.640

7.  Localization and hypersecretion of nerve growth factor in breast phyllodes tumors: Evidence from a preliminary study.

Authors:  Ashutosh Kumar; Khursheed Raza; Tapas C Nag; Anurag Srivastava; Ritu Sehgal
Journal:  Cancer Rep (Hoboken)       Date:  2020-10-07
  7 in total

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