PURPOSE: To assess the potential for reduction of contrast material dose in hepatic spiral computed tomography (CT). MATERIALS AND METHODS: Four hundred eighty-seven outpatients were randomized prospectively into nine biphasic and eight uniphasic injection protocols: 75, 100, or 125 mL of 240, 300, or 350 mg of iodine per milliliter of iohexol (18-44 grams of iodine). Protocols were compared according to the maximum hepatic enhancement (MAX) and the contrast enhancement index (CEI). RESULTS:Uniphasic injection was superior to biphasic injection for all protocols. No statistically significant difference in contrast enhancement was present for 38-44 grams of iodine with the uniphasic technique. Adequate enhancement thresholds (MAX > 50 HU, CEI at 30 HU > 300 HU x sec) were exceeded in more than 70% of heavy patients ( > 183 lb [83 kg]) with uniphasic injection of 38 g. For thin patients ( < 183 lb [83 kg]), uniphasic injection of 26 g produced adequate enhancement. CONCLUSION: Contrast material dose may be reduced by up to 40% in thin patients undergoing hepatic spiral CT after uniphasic injection of contrast material; this may result in substantial cost savings.
RCT Entities:
PURPOSE: To assess the potential for reduction of contrast material dose in hepatic spiral computed tomography (CT). MATERIALS AND METHODS: Four hundred eighty-seven outpatients were randomized prospectively into nine biphasic and eight uniphasic injection protocols: 75, 100, or 125 mL of 240, 300, or 350 mg of iodine per milliliter of iohexol (18-44 grams of iodine). Protocols were compared according to the maximum hepatic enhancement (MAX) and the contrast enhancement index (CEI). RESULTS: Uniphasic injection was superior to biphasic injection for all protocols. No statistically significant difference in contrast enhancement was present for 38-44 grams of iodine with the uniphasic technique. Adequate enhancement thresholds (MAX > 50 HU, CEI at 30 HU > 300 HU x sec) were exceeded in more than 70% of heavy patients ( > 183 lb [83 kg]) with uniphasic injection of 38 g. For thin patients ( < 183 lb [83 kg]), uniphasic injection of 26 g produced adequate enhancement. CONCLUSION: Contrast material dose may be reduced by up to 40% in thin patients undergoing hepatic spiral CT after uniphasic injection of contrast material; this may result in substantial cost savings.
Authors: C N De Cecco; V Buffa; S Fedeli; A Vallone; R Ruopoli; M Luzietti; V Miele; M Rengo; M Maurizi Enrici; P Fina; A Laghi; V David Journal: Radiol Med Date: 2010-09-17 Impact factor: 3.469
Authors: F F Behrendt; A H Mahnken; S Keil; M Das; C Hohl; D Bauer; P Seidensticker; E Jost; J E Wildberger; R W Günther; G Mühlenbruch Journal: Eur Radiol Date: 2008-01-29 Impact factor: 5.315
Authors: Florian F Behrendt; Hubertus Pietsch; Gregor Jost; Martin A Sieber; Sebastian Keil; Cedric Plumhans; Peter Seidensticker; Rolf W Günther; Andreas H Mahnken Journal: Eur Radiol Date: 2010-02-24 Impact factor: 5.315
Authors: Helmut Schoellnast; Manfred Tillich; Hannes A Deutschmann; Uwe Stessel; Michael J Deutschmann; Gottfried J Schaffler; Renate Schoellnast; Martin M Uggowitzer Journal: Eur Radiol Date: 2003-10-18 Impact factor: 5.315