Literature DB >> 7568013

Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones.

Y Muragaki1, S Timmons, C M Griffith, S P Oh, B Fadel, T Quertermous, B R Olsen.   

Abstract

We have isolated overlapping cDNAs encoding the N-terminal non-triple-helical region of mouse alpha 1(XVIII) collagen and shown that three different variants of alpha 1(XVIII) collagen exist. Each of the three variants shows characteristic tissue-specific expression patterns. Immunohistochemical studies show positive staining for alpha 1(XVIII) collagen along the basement membrane zones of vessels in the intestinal villi, the choroid plexus, skin, liver, and kidney. Thus, we conclude that alpha 1(XVIII) collagen may interact (directly or indirectly) with components in basement membrane zones or on the basal surface of endothelial/epithelial cells.

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Year:  1995        PMID： 7568013      PMCID： PMC41047          DOI： 10.1073/pnas.92.19.8763

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

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Authors:  D J Hulmes
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6.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

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  49 in total

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10.  The short and long forms of type XVIII collagen show clear tissue specificities in their expression and location in basement membrane zones in humans.

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