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Literature DB >> 2174014

Molecular structure of frizzled, a Drosophila tissue polarity gene.

P N Adler¹, C Vinson, W J Park, S Conover, L Klein.

Abstract

The function of the frizzled (fz) locus is required to coordinate the cytoskeletons of pupal epidermal cells so that a parallel array of cuticular hairs and bristles is produced. We report here the molecular cloning and characterization of the fz locus. The locus is very large. Mutations that inactivate the gene are spread over 100 kb of genomic DNA. The major mRNA product of the gene is a 4-kb RNA that is encoded by 5 exons spread over more than 90 kb of genomic DNA. Conceptual translation of this mRNA indicates that it encodes an integral membrane protein that is likely to contain both extracellular and cytoplasmic domains.

Entities: Gene Species

Mesh：

Substances：

Year: 1990 PMID： 2174014 PMCID： PMC1204194

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

42 in total

1. A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains.

Authors: C R Vinson; S Conover; P N Adler
Journal: Nature Date: 1989-03-16 Impact factor: 49.962

2. Improved programs for DNA and protein sequence analysis on the IBM personal computer and other standard computer systems.

Authors: D W Mount; B Conrad
Journal: Nucleic Acids Res Date: 1986-01-10 Impact factor: 16.971

3. Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates.

Authors: D R Cavener
Journal: Nucleic Acids Res Date: 1987-02-25 Impact factor: 16.971

4. The Notch locus of Drosophila melanogaster.

Authors: S Kidd; T J Lockett; M W Young
Journal: Cell Date: 1983-09 Impact factor: 41.582

5. Transposition of cloned P elements into Drosophila germ line chromosomes.

Authors: A C Spradling; G M Rubin
Journal: Science Date: 1982-10-22 Impact factor: 47.728

6. Lambda replacement vectors carrying polylinker sequences.

Authors: A M Frischauf; H Lehrach; A Poustka; N Murray
Journal: J Mol Biol Date: 1983-11-15 Impact factor: 5.469

7. A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster.

Authors: D Gubb; A García-Bellido
Journal: J Embryol Exp Morphol Date: 1982-04

8. A new computer method for the storage and manipulation of DNA gel reading data.

Authors: R Staden
Journal: Nucleic Acids Res Date: 1980-08-25 Impact factor: 16.971

9. Molecular cloning of sequences from a Drosophila RNA polymerase II locus by P element transposon tagging.

Authors: L L Searles; R S Jokerst; P M Bingham; R A Voelker; A L Greenleaf
Journal: Cell Date: 1982-12 Impact factor: 41.582

10. Cloning of DNA sequences from the white locus of D. melanogaster by a novel and general method.

Authors: P M Bingham; R Levis; G M Rubin
Journal: Cell Date: 1981-09 Impact factor: 41.582

28 in total

1. The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs.

Authors: D Gubb; C Green; D Huen; D Coulson; G Johnson; D Tree; S Collier; J Roote
Journal: Genes Dev Date: 1999-09-01 Impact factor: 11.361

10. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.

Authors: J D Axelrod; J R Miller; J M Shulman; R T Moon; N Perrimon
Journal: Genes Dev Date: 1998-08-15 Impact factor: 11.361

Molecular structure of frizzled, a Drosophila tissue polarity gene.

1. A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains.

2. Improved programs for DNA and protein sequence analysis on the IBM personal computer and other standard computer systems.

3. Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates.

4. The Notch locus of Drosophila melanogaster.

5. Transposition of cloned P elements into Drosophila germ line chromosomes.

6. Lambda replacement vectors carrying polylinker sequences.

7. A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster.

8. A new computer method for the storage and manipulation of DNA gel reading data.

9. Molecular cloning of sequences from a Drosophila RNA polymerase II locus by P element transposon tagging.

10. Cloning of DNA sequences from the white locus of D. melanogaster by a novel and general method.

1. The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs.

Review 2. The role of the E-cadherin complex in gastrointestinal cell differentiation.

3. Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation.

4. New nucleotide sequence data on the EMBL File Server.

Review 5. Winding through the WNT pathway during cellular development and demise.

6. Modeling the control of planar cell polarity.

7. Wingless activity in the precursor cells specifies neuronal migratory behavior in the Drosophila nerve cord.

Review 8. The Wnt signaling pathway: aging gracefully as a protectionist?

Review 9. Primary cilia in planar cell polarity regulation of the inner ear.

10. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.