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Literature DB >> 7450752

The fragile site on chromosome 16 (q21q22). Data on four new families.

Abstract

The significance of the fragile site on 16 (q21q22) has not yet been fully evaluated. New data will contribute to the understanding of this cytogenetic finding. Therefore we report on four families where a chromosome 16 with fragile site was segregating and such problems as infertility, abortions, malformations, and aneuploidy were present. The hypothesis that this fragile site is a site of viral modification (or integration?) is considered.

Entities: Disease Gene

Mesh：

Year: 1980 PMID： 7450752 DOI： 10.1007/bf00329121

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

11 in total

1. Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium.

Authors: G R Sutherland
Journal: Science Date: 1977-07-15 Impact factor: 47.728

2. Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

Authors: G R Sutherland
Journal: Am J Hum Genet Date: 1979-03 Impact factor: 11.025

3. Cytogenetic investigation in 413 couples with spontaneous abortions.

Authors: C Turleau; F Chavin-Colin; J de Grouchy
Journal: Eur J Obstet Gynecol Reprod Biol Date: 1979-04 Impact factor: 2.435

4. A cascade of chromosomal aberrations in three generations: a fragile 16q, an extra fragment and a rearranged 20.

Authors: G B Côté; S Papadakou-Lagoyanni; S Pantelakis
Journal: Ann Genet Date: 1978-12

5. Deleted chromosome 18 with paternal mosaicism.

Authors: E J Day; R Marshall; P A MacDonald; W M Davidson
Journal: Lancet Date: 1967-12-16 Impact factor: 79.321

6. Double heteroploidy, 46, XY, t(13q14q), +18, in a spontaneous abortus.

Authors: S Avirachan; T Kajii
Journal: Clin Genet Date: 1973 Impact factor: 4.438

7. Heritable fragile site on chromosome 16: probable localization of haptoglobin locus in man.

Authors: R E Magenis; F Hecht; E W Lovrien
Journal: Science Date: 1970-10-02 Impact factor: 47.728

8. Localization of the human alpha-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay.

Authors: A Deisseroth; A Nienhuis; P Turner; R Velez; W F Anderson; F Ruddle; J Lawrence; R Creagan; R Kucherlapati
Journal: Cell Date: 1977-09 Impact factor: 41.582

8. Familial fragile site found at the cancer breakpoint (1)(q32). Inducibility by distamycin A, concomitance with fragile (16)(q22).

Authors: F Shabtai; J Hart; D Klar; I Halbrecht
Journal: Hum Genet Date: 1986-07 Impact factor: 4.132

8 in total

The fragile site on chromosome 16 (q21q22). Data on four new families.

1. Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium.

2. Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

3. Cytogenetic investigation in 413 couples with spontaneous abortions.

4. A cascade of chromosomal aberrations in three generations: a fragile 16q, an extra fragment and a rearranged 20.

5. Deleted chromosome 18 with paternal mosaicism.

6. Double heteroploidy, 46, XY, t(13q14q), +18, in a spontaneous abortus.

7. Heritable fragile site on chromosome 16: probable localization of haptoglobin locus in man.

8. Localization of the human alpha-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay.

9. Constitutional chromosomal breakage.

10. Fragile site long arm chromosome 16.

1. Different inducibility and possible significance of several concomitant "fragile sites" in two brothers.

2. The fragile site (16) (q22). I. Induction by AT-specific DNA-ligands and population frequency.

3. Alpha-interferon and fragility at 16q22. A study on 15 selected controls and 146 selected patients.

4. Enhanced Expression of FRA16B using AT-Rich DNA Binding Chemicals in a Woman with Secondary Amenorrhoea.

5. Fragile chromosome 16(q22) cause a balanced translocation at the same point.

6. Familial fragility on chromosome 16 (fra 16q22) enhanced by both interferon and Distamycin A.

7. The use of distamycin A in human lymphocyte cultures.

8. Familial fragile site found at the cancer breakpoint (1)(q32). Inducibility by distamycin A, concomitance with fragile (16)(q22).