Literature DB >> 5452897

Heritable fragile site on chromosome 16: probable localization of haptoglobin locus in man.

R E Magenis, F Hecht, E W Lovrien.   

Abstract

We have found recurrent chromosome breaks at a site (the "fragile site") on the long arm of chromosome 16. This site segregates in simple Mendelian dominant fashion in a large family. The distal portion of the chromosome sometimes shows selective endoreduplication. Preliminary linkage results reveal only 3 recombinants in 33 opportunities for recombination between the fragile site and the alpha locus of haptoglobin, an indication that the alpha-Hp gene is located near this region on chromosome 16.

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Year:  1970        PMID： 5452897     DOI： 10.1126/science.170.3953.85

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  49 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 2.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 3.  The role of fork stalling and DNA structures in causing chromosome fragility.

Authors:  Simran Kaushal; Catherine H Freudenreich
Journal:  Genes Chromosomes Cancer       Date:  2019-01-29       Impact factor: 5.006

4.  A linkage group with FRA16B (the fragile site at 16q22.1).

Authors:  J C Mulley; V J Hyland; A Fratini; L J Bates; A K Gedeon; G R Sutherland
Journal:  Hum Genet       Date:  1989-05       Impact factor: 4.132

5.  Rare, polymorphic, and common fragile sites: a classification.

Authors:  F Hecht
Journal:  Hum Genet       Date:  1986-10       Impact factor: 4.132

6.  The importance of being a fragile site.

Authors:  F Hecht; B Kaiser-McCaw
Journal:  Am J Hum Genet       Date:  1979-03       Impact factor: 11.025

7.  The constitutional fragility of chromosome 12 in a case of 46,XX,var(12)(gh',RHG,CAG,CBG).

Authors:  E Donti; G Venti; V Bocchini; G Rosi; R Armellini; N Trabalza
Journal:  Hum Genet       Date:  1979-04-17       Impact factor: 4.132

8.  Chromosomal mosaicism in amniotic fluid cell cultures.

Authors:  D C Peakman; M F Moreton; B J Corn; A Robinson
Journal:  Am J Hum Genet       Date:  1979-03       Impact factor: 11.025

9.  Fragile site long arm chromosome 16.

Authors:  K Sørensen; J Nielsen; V Holm; J Haahr
Journal:  Hum Genet       Date:  1979-04-17       Impact factor: 4.132

10.  Chromosome breakages associated with 45S ribosomal DNA sequences in spotted snakehead fish Channa punctatus.

Authors:  Mamta Singh; Anindya Sundar Barman
Journal:  Mol Biol Rep       Date:  2012-10-12       Impact factor: 2.316
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