Literature DB >> 3019870

Different inducibility and possible significance of several concomitant "fragile sites" in two brothers.

F Shabtai, J Orlin, J Hart, I Halbrecht, D Klar, J Friedman.   

Abstract

Concomitance of four fragile sites (at 16p13, 16q22, 16q23, Yq12) in the lymphocyte cultures of two brothers is reported. The expression of each of these fragile sites was enhanced (or induced) by different culture conditions. Some of the inducing conditions are already known and others are reported here for the first time. The meaning of the fragile sites is discussed and a possible viral etiology suggested. Concomitance of some of them may be a potential causal factor for deletions, translocations, or inversions.

Mesh：

Year:  1986        PMID： 3019870     DOI： 10.1007/bf00278791

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  23 in total

1.  Alpha-interferon and fragility at 16q22. A study on 15 selected controls and 146 selected patients.

Authors:  F Shabtai; J Orlyn; J Hart; S Bichacho; I Halbrecht
Journal:  Hum Genet       Date:  1987-01       Impact factor: 4.132

2.  Heritable fragile sites in cancer.

Authors:  M M LeBeau; J D Rowley
Journal:  Nature       Date:  1984 Apr 12-18       Impact factor: 49.962

3.  Cancer chromosome breakpoints and common fragile sites induced by aphidicolin.

Authors:  F Hecht; T W Glover
Journal:  Cancer Genet Cytogenet       Date:  1984-10

4.  The fragile site on chromosome 16 (q21q22). Data on four new families.

Authors:  F Shabtai; S Bichacho; I Halbrecht
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

5.  Chromium chloride induces chromosomal aberrations in human lymphocytes via indirect action.

Authors:  J Friedman; F Shabtai; L S Levy; M Djaldetti
Journal:  Mutat Res       Date:  1987 Jul-Aug       Impact factor: 2.433

6.  X-linked mental retardation with fragile X. A pedigree showing transmission by apparently unaffected males and partial expression in female carriers.

Authors:  K B Nielsen; N Tommerup; H Poulsen; M Mikkelsen
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

7.  Constitutive fragile sites and cancer.

Authors:  J J Yunis; A L Soreng
Journal:  Science       Date:  1984-12-07       Impact factor: 47.728

8.  The use of distamycin A in human lymphocyte cultures.

Authors:  M Schmid; D A Hungerford; A Poppen; W Engel
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

9.  Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia.

Authors:  M M Le Beau; M O Diaz; M Karin; J D Rowley
Journal:  Nature       Date:  1985 Feb 21-27       Impact factor: 49.962

10.  Heritable fragile sites on human chromosomes. XI. Factors affecting expression of fragile sites at 10q25, 16q22, and 17p12.

Authors:  G R Sutherland; P B Jacky; E G Baker
Journal:  Am J Hum Genet       Date:  1984-01       Impact factor: 11.025
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  4 in total

1.  Alpha-interferon and fragility at 16q22. A study on 15 selected controls and 146 selected patients.

Authors:  F Shabtai; J Orlyn; J Hart; S Bichacho; I Halbrecht
Journal:  Hum Genet       Date:  1987-01       Impact factor: 4.132

2.  Expression of folate-sensitive fragile sites in lymphocyte chromosomes.

Authors:  C Fuster; R Miró; C Templado; L Barrios; J Egozcue
Journal:  Hum Genet       Date:  1989-02       Impact factor: 4.132

3.  Familial fragile site found at the cancer breakpoint (1)(q32). Inducibility by distamycin A, concomitance with fragile (16)(q22).

Authors:  F Shabtai; J Hart; D Klar; I Halbrecht
Journal:  Hum Genet       Date:  1986-07       Impact factor: 4.132

4.  Can sister chromatid intercrossings be considered as prelesions?

Authors:  C Fuster; R Mirò; C Templado; L Barrios; J Egozcue
Journal:  Hum Genet       Date:  1988-06       Impact factor: 4.132
  4 in total

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