Literature DB >> 7333265

Dose-response analysis in animal studies: prediction of human responses.

Y Alarie.   

Abstract

An animal bioassay has been used to evaluate a series of airborne chemicals for their sensory irritating properties to the upper respiratory tract. Teh results obtained can be used to rank their potency. An attempt has been made to predict "safe" levels of exposure for humans on the basis of this short-term assay. A good correlation was obtained between the predicted "safe" levels of exposure and current Threshold Limit Values established for industrial exposures.

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Year:  1981        PMID： 7333265      PMCID： PMC1568799          DOI： 10.1289/ehp.81429

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  7 in total

1.  Sensory irritation by toluene diisocyanate in single and repeated exposures.

Authors:  G K Sangha; Y Alarie
Journal:  Toxicol Appl Pharmacol       Date:  1979-09-30       Impact factor: 4.219

Review 2.  Sensory irritation by airborne chemicals.

Authors:  Y Alarie
Journal:  CRC Crit Rev Toxicol       Date:  1973-11

3.  Risk of angiosarcoma in workers exposed to vinyl chloride as predicted from studies in rats.

Authors:  P J Gehring; P G Watanabe; C N Park
Journal:  Toxicol Appl Pharmacol       Date:  1979-06-15       Impact factor: 4.219

4.  Evaluation of sensory irritation from some common industrial solvents.

Authors:  L E Kane; R Dombroske; Y Alarie
Journal:  Am Ind Hyg Assoc J       Date:  1980-06

5.  A short-term test to predict acceptable levels of exposure to airborne sensory irritants.

Authors:  L E Kane; C S Barrow; Y Alarie
Journal:  Am Ind Hyg Assoc J       Date:  1979-03

6.  Irritating properties of airborne materials to the upper respiratory tract.

Authors:  Y Alarie
Journal:  Arch Environ Health       Date:  1966-10

7.  Hazardous substances, the environment and public health: a statistical overview.

Authors:  W G Hunter; J J Crowley
Journal:  Environ Health Perspect       Date:  1979-10       Impact factor: 9.031
  7 in total
  11 in total

1.  The effects of n-butanol vapour on respiratory rate and tidal volume.

Authors:  U Kristiansen; A M Vinggaard; G D Nielsen
Journal:  Arch Toxicol       Date:  1988-01       Impact factor: 5.153

2.  Activation of the sensory irritant receptor by C7-C11 n-alkanes.

Authors:  U Kristiansen; G D Nielsen
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

3.  Sensory irritation and pulmonary irritation of n-methyl ketones: receptor activation mechanisms and relationships with threshold limit values.

Authors:  L F Hansen; G D Nielsen
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

Review 4.  Local effects in the respiratory tract: relevance of subjectively measured irritation for setting occupational exposure limits.

Authors:  Josje H E Arts; Cees de Heer; Ruud A Woutersen
Journal:  Int Arch Occup Environ Health       Date:  2005-11-08       Impact factor: 3.015

5.  Inhalation delivery of proteins from ethanol suspensions.

Authors:  W S Choi; G G Murthy; D A Edwards; R Langer; A M Klibanov
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-18       Impact factor: 11.205

6.  In silico approaches in organ toxicity hazard assessment: Current status and future needs for predicting heart, kidney and lung toxicities.

Authors:  Arianna Bassan; Vinicius M Alves; Alexander Amberg; Lennart T Anger; Lisa Beilke; Andreas Bender; Autumn Bernal; Mark T D Cronin; Jui-Hua Hsieh; Candice Johnson; Raymond Kemper; Moiz Mumtaz; Louise Neilson; Manuela Pavan; Amy Pointon; Julia Pletz; Patricia Ruiz; Daniel P Russo; Yogesh Sabnis; Reena Sandhu; Markus Schaefer; Lidiya Stavitskaya; David T Szabo; Jean-Pierre Valentin; David Woolley; Craig Zwickl; Glenn J Myatt
Journal:  Comput Toxicol       Date:  2021-09-13

7.  Emergency planning and the acute toxic potency of inhaled ammonia.

Authors:  R A Michaels
Journal:  Environ Health Perspect       Date:  1999-08       Impact factor: 9.031

Review 8.  Use of biological markers and pharmacokinetics in human health risk assessment.

Authors:  D Hattis
Journal:  Environ Health Perspect       Date:  1991-01       Impact factor: 9.031

9.  Odor thresholds and breathing changes of human volunteers as consequences of sulphur dioxide exposure considering individual factors.

Authors:  Stefan Kleinbeck; Michael Schäper; Stephanie A Juran; Ernst Kiesswetter; Meinolf Blaszkewicz; Klaus Golka; Anna Zimmermann; Thomas Brüning; Christoph Van Thriel
Journal:  Saf Health Work       Date:  2011-12-05

10.  Evaluation and application of the RD50 for determining acceptable exposure levels of airborne sensory irritants for the general public.

Authors:  Yu Kuwabara; George V Alexeeff; Rachel Broadwin; Andrew G Salmon
Journal:  Environ Health Perspect       Date:  2007-11       Impact factor: 9.031
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