Literature DB >> 1111095

5-methyltetrahydrofolic acid is not a methyl donor for biogenic amines: enzymatic formation of formaldehyde.

E Meller, H Rosengarten, A J Friedhoff, R D Stebbins, R Silber.   

Abstract

Contrary to previous reports, 5-methyltetrahydrofolic acid does not mediate the methylation of dopamine to epinine. Instead, this methyl donor is degraded enzymatically to formaldehyde, which condenses with dopamine to form a tetahydoisoquinoline derivative. The latter has chromotographic characteristics very similar to those of epinine, which likely accounts for the original misidentification of the product.

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Year:  1975        PMID： 1111095     DOI： 10.1126/science.1111095

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Prebiotic methylation and the evolution of methyl transfer reactions in living cells.

Authors:  T G Waddell; L L Eilders; B P Patel; M Sims
Journal:  Orig Life Evol Biosph       Date:  2000-12       Impact factor: 1.950

2.  Lack of epinine formation in adrenal medulla and brain of rats during cold exposure and inhibition of dopamine beta-hydroxylase.

Authors:  H J Schümann; O E Brodde
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-05       Impact factor: 3.000

3.  6-Hydroxy-tetrahydronorharmane (6-hydroxy-tetrahydro-beta-carboline), a new active metabolite of indole-alkylamines in man and rat.

Authors:  H Rommelspacher; H Honecker; M Barbey; B Meinke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-12       Impact factor: 3.000

4.  Pathology of folate deficiency.

Authors:  A V Hoffbrand
Journal:  Proc R Soc Med       Date:  1977-02

Review 5.  Drugs and folate metabolism.

Authors:  D G Lambie; R H Johnson
Journal:  Drugs       Date:  1985-08       Impact factor: 9.546

6.  Tetrahydronorharmane (tetrahydro-beta-carboline), a physiologically occurring compound of indole metabolism.

Authors:  H Honecker; H Rommelspacher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-11       Impact factor: 3.000

7.  Inhibition of 5-hydroxytryptamine uptake by tetrahydronorharmane in vivo.

Authors:  H Rommelspacher; S Strauss; C H Cohnitz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-07       Impact factor: 3.000

8.  Folate metabolism in the superior cervical ganglion histochemical study.

Authors:  I Diculescu; D Onicescu
Journal:  Histochemistry       Date:  1979-07

9.  Methyl Metabolism and the Clock: An Ancient Story With New Perspectives.

Authors:  Jean-Michel Fustin
Journal:  J Biol Rhythms       Date:  2022-04-05       Impact factor: 3.649
  9 in total

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