Literature DB >> 7232216

Conformational changes of poly(dG-dC) . poly(dG-dC) modified by the carcinogen N-acetoxy-N-acetyl-2-aminofluorene.

E Sage, M Leng.   

Abstract

Poly (dG-dC) . poly(dG-dC) was modified by the reaction with N-acetoxy-N-acetyl-2-aminofluorene. The conformations of poly(dG-dC) . poly(dG-dC) and of poly d(G-C)AAF were studied by circular dichroism under various experimental conditions. In 95% ethanol, the two polynucleotides adopt the A-form. In 3.9 M LiCl, the transition B-form-C-form is observed with poly(dG-dC) . poly (dG-dC) but not with poly d(G-C)AAF. In 1 mM phosphate buffer, poly d(G-C)AAF behaves as a mixture of B- and Z-form, the relative percentages depending upon the amounts of modified bases. The percentage of Z-form is decreased by addition of EDTA and is increased by addition of Mg++. Spermine favors the Z-form in modified and unmodified polynucleotides. No defect in the double helix of poly d(G-C)AAF is detected by SI endonuclease.

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Year:  1981        PMID： 7232216      PMCID： PMC326749          DOI： 10.1093/nar/9.5.1241

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  19 in total

1.  In vitro recognition of carcinogen-induced local denaturation sites native DNA by S1 endonuclease from Aspergillus oryzae.

Authors:  R P Fuchs
Journal:  Nature       Date:  1975-09-11       Impact factor: 49.962

2.  Polymorphism of a synthetic DNA in solution.

Authors:  F M Pohl
Journal:  Nature       Date:  1976-03-25       Impact factor: 49.962

3.  Circular dichroism of mitomycin-DNA complexes. Evidence for a conformational change in DNA.

Authors:  C M Mercado; M Tomasz
Journal:  Biochemistry       Date:  1977-05-03       Impact factor: 3.162

4.  Physical basis of chemical carcinogenesis by N-2-fluorenylacetamide derivatives and analogs.

Authors:  R Fuchs; M Daune
Journal:  FEBS Lett       Date:  1973-08-15       Impact factor: 4.124

5.  Circular dichroism spectra of oriented and unoriented deoxyribonucleic acid films--a preliminary study.

Authors:  M J Tunis-Schneider; M F Maestre
Journal:  J Mol Biol       Date:  1970-09-28       Impact factor: 5.469

6.  Different conformations of double-stranded nucleic acid in solution as revealed by circular dichroism.

Authors:  V I Ivanov; L E Minchenkova; A K Schyolkina; A I Poletayev
Journal:  Biopolymers       Date:  1973       Impact factor: 2.505

7.  Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).

Authors:  F M Pohl; T M Jovin
Journal:  J Mol Biol       Date:  1972-06-28       Impact factor: 5.469

8.  Does DNA adopt the C form in concentrated salt solutions or in organic solvent water mixtures? An x-ray diffraction study of DNA fibers immersed in various media.

Authors:  S B Zimmerman; B H Pheiffer
Journal:  J Mol Biol       Date:  1980-09-25       Impact factor: 5.469

9.  Adduct formation between the carcinogen N-acetoxy-2-acetylaminofluorene and synthetic polydeoxyribonucleotides.

Authors:  D J Harvan; J R Hass; M W Lieberman
Journal:  Chem Biol Interact       Date:  1977-05       Impact factor: 5.192

10.  Effect of N-2-acetylaminofluorene modification on the structure and template activity of DNA and reconstituted chromatin.

Authors:  H Yamasaki; S Leffler; I B Weinstein
Journal:  Cancer Res       Date:  1977-03       Impact factor: 12.701
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  23 in total

1.  Evidence for a new Z-type left-handed DNA helix: properties of Z(WC)-DNA.

Authors:  A T Ansevin; A H Wang
Journal:  Nucleic Acids Res       Date:  1990-10-25       Impact factor: 16.971

2.  Kinetics of exchangeable protons in Z DNA: a UV resonance Raman study.

Authors:  A Laigle; L Chinsky; P Y Turpin; B Jollès
Journal:  Nucleic Acids Res       Date:  1989-04-11       Impact factor: 16.971

3.  Z-DNA-forming sequences are spontaneous deletion hot spots.

Authors:  A M Freund; M Bichara; R P Fuchs
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

4.  uvrC gene function has no specific role in repair of N-2-aminofluorene adducts.

Authors:  M Bichara; R P Fuchs
Journal:  J Bacteriol       Date:  1987-01       Impact factor: 3.490

5.  Z DNA and loop structures by immunoelectronmicroscopy of supercoiled pRW751, a plasmid containing left-handed helices.

Authors:  H Castleman; L H Hanau; W Zacharias; B F Erlanger
Journal:  Nucleic Acids Res       Date:  1988-05-11       Impact factor: 16.971

6.  Induction of prolactin-deficient variants of GH3 rat pituitary tumor cells by ethyl methanesulfonate: reversion by 5-azacytidine, a DNA methylation inhibitor.

Authors:  R D Ivarie; J A Morris
Journal:  Proc Natl Acad Sci U S A       Date:  1982-05       Impact factor: 11.205

7.  Simultaneous stability of short alternating Z and B helices in synthetic DNA concatamers.

Authors:  F Quadrifoglio; G Manzini; K Dinkelspiel; R Crea
Journal:  Nucleic Acids Res       Date:  1982-06-25       Impact factor: 16.971

8.  Conformational transitions of poly(dA-dC).poly(dG-dT) induced by high salt or in ethanolic solution.

Authors:  C Zimmer; S Tymen; C Marck; W Guschlbauer
Journal:  Nucleic Acids Res       Date:  1982-02-11       Impact factor: 16.971

9.  The B goes to Z transition of poly(dG-dC) . poly(dG-dC) modified by some platinum derivatives.

Authors:  B Malfoy; B Hartmann; M Leng
Journal:  Nucleic Acids Res       Date:  1981-11-11       Impact factor: 16.971

10.  Interaction of DNA methyltransferase with aminofluorene and N-acetylaminofluorene modified poly(dC-dG).

Authors:  M Ruchirawat; F F Becker; J N Lapeyre
Journal:  Nucleic Acids Res       Date:  1984-04-11       Impact factor: 16.971
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