Literature DB >> 18291

Adduct formation between the carcinogen N-acetoxy-2-acetylaminofluorene and synthetic polydeoxyribonucleotides.

D J Harvan, J R Hass, M W Lieberman.   

Abstract

The chemical carcinogen N-acetoxy-2-acetylaminofluorene (NA-AAF) was reacted with poly(dG-dC) - poly(dG-dC); poly dG - poly dC; poly(dA-dT) - poly (dA-dT); and poly dA - poly dT under a variety of conditions. Poly (dG-homo GC polymer and 10--20 more reactive the A + T polymers. Lowering the ionic strength increased the extent of reaction, while pH change (8.9 vs. 5.5) had only a small effect. If ionic strength was adjusted so that the two guanine-containing polymers showed equal thermal stability (as judged by Tm) then the alternating copolymer was 7 times as reactive as the homopolymer. In aggreement with previous investigators, the major product was found to be 8-(N-2-fluorenylacetamido) deoxyguanosine.

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Year:  1977        PMID： 18291     DOI： 10.1016/0009-2797(77)90085-0

Source DB:  PubMed          Journal:  Chem Biol Interact        ISSN： 0009-2797            Impact factor:   5.192


  7 in total

1.  Recognition of chemical carcinogen-modified DNA by a DNA-binding protein.

Authors:  F Moranelli; M W Lieberman
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

2.  Conformations of poly(dG-dC).poly(dG-dC) modified by the O-acetyl derivative of the carcinogen 4-hydroxyaminoquinoline 1-oxide.

Authors:  B Bailleul; S Galiègue-Zouitina; M H Loucheux-Lefebvre
Journal:  Nucleic Acids Res       Date:  1984-10-25       Impact factor: 16.971

3.  Conformation of poly(dG-dC) . poly(dG-dC) modified by the carcinogens N-acetoxy-N-acetyl-2-aminofluorene and N-hydroxy-N-2-aminofluorene.

Authors:  E Sage; M Leng
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205

4.  Differential inhibition of rat liver DNA polymerases in vitro by direct-acting carcinogens and the protective effect of a thiol reducing agent.

Authors:  J Y Chan; F F Becker
Journal:  Biochem J       Date:  1981-03-01       Impact factor: 3.857

5.  Conformational changes of poly(dG-dC) . poly(dG-dC) modified by the carcinogen N-acetoxy-N-acetyl-2-aminofluorene.

Authors:  E Sage; M Leng
Journal:  Nucleic Acids Res       Date:  1981-03-11       Impact factor: 16.971

6.  Induction of the base displacement or Z conformation in DNA by N-2-acetylaminofluorene modification.

Authors:  R M Santella; D Grunberger
Journal:  Environ Health Perspect       Date:  1983-03       Impact factor: 9.031

Review 7.  Computer-assisted mechanistic structure-activity studies: application to diverse classes of chemical carcinogens.

Authors:  G H Loew; M Poulsen; E Kirkjian; J Ferrell; B S Sudhindra; M Rebagliati
Journal:  Environ Health Perspect       Date:  1985-09       Impact factor: 9.031
  7 in total

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