Literature DB >> 7177849

Polymer supported synthesis of oligonucleotides by a phosphotriester method.

R Belagaje, C K Brush.   

Abstract

A new polymer supported synthesis of deoxyribooligonucleotides which can be adapted to automation is described. The method is based on the elongation of an oligomer chain in the 5'- to 3' -end direction using the modified phosphotriester chemistry. The approach is exemplified by the synthesis of a nonanucleotide d(TTCGTCTTG).

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Year:  1982        PMID： 7177849      PMCID： PMC326919          DOI： 10.1093/nar/10.20.6295

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  10 in total

Review 1.  Synthetic oligodeoxynucleotides for analyses of DNA structure and function.

Authors:  R Wu; C P Bahl
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1978

2.  Chemical synthesis and cloning of a tyrosine tRNA gene.

Authors:  E L Brown; R Belagaje; M J Ryan; H G Khorana
Journal:  Methods Enzymol       Date:  1979       Impact factor: 1.600

3.  Automated synthesis of gene fragments.

Authors:  G Alvarado-Urbina; G M Sathe; W C Liu; M F Gillen; P D Duck; R Bender; K K Ogilvie
Journal:  Science       Date:  1981-10-16       Impact factor: 47.728

4.  Total synthesis of a human leukocyte interferon gene.

Authors:  M D Edge; A R Green; G R Heathcliffe; P A Meacock; W Schuch; D B Scanlon; T C Atkinson; C R Newton; A F Markham
Journal:  Nature       Date:  1981-08-20       Impact factor: 49.962

5.  Chemical DNA synthesis and recombinant DNA studies.

Authors:  K Itakura; A D Riggs
Journal:  Science       Date:  1980-09-19       Impact factor: 47.728

6.  Improved phosphotriester method for the synthesis of gene fragments.

Authors:  S A Narang; H M Hsiung; R Brousseau
Journal:  Methods Enzymol       Date:  1979       Impact factor: 1.600

7.  New chemical methods for synthesizing polynucleotides.

Authors:  M H Caruthers; S L Beaucage; J W Efcavitch; E F Fisher; M D Matteucci; Y Stabinsky
Journal:  Nucleic Acids Symp Ser       Date:  1980

8.  Chemical synthesis of genes for human insulin.

Authors:  R Crea; A Kraszewski; T Hirose; K Itakura
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

9.  Solid phase synthesis of oligonucleotides on a crosslinked polyacrylmorpholide support.

Authors:  K E Norris; F Norris; K Brunfeldt
Journal:  Nucleic Acids Symp Ser       Date:  1980

10.  Synthesis of oligonucleotides on cellulose. Part II: Design and synthetic strategy to the synthesis of 22 oligodeoxynucleotides coding for gastric inhibitory polypeptide (GIP).

Authors:  T Horn; M P Vasser; M E Struble; R Crea
Journal:  Nucleic Acids Symp Ser       Date:  1980
  10 in total
  1 in total

1.  An approach to the stereoselective synthesis of Sp-dinucleoside phosphorothioates using phosphotriester chemistry.

Authors:  R Cosstick; D M Williams
Journal:  Nucleic Acids Res       Date:  1987-12-10       Impact factor: 16.971
  1 in total

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