Literature DB >> 6265873

Synthesis of oligonucleotides on cellulose. Part II: Design and synthetic strategy to the synthesis of 22 oligodeoxynucleotides coding for gastric inhibitory polypeptide (GIP).

T Horn, M P Vasser, M E Struble, R Crea.   

Abstract

A solid-phase approach using trinucleotide building blocks and functionalized cellulose as solid support was used to synthesize the 22 oligodeoxynucleotides that constitute a totally synthetic gene coding for a 43 amino acid peptide. Gastric inhibitory Polypeptide. The overall strategy used for the design and synthesis of the oligomers is described.

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Year:  1980        PMID： 6265873

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser        ISSN： 0261-3166


  6 in total

1.  Improvements to solid phase phosphotriester synthesis of deoxyoligonucleotides.

Authors:  T P Patel; T A Millican; C C Bose; R C Titmas; G A Mock; M A Eaton
Journal:  Nucleic Acids Res       Date:  1982-09-25       Impact factor: 16.971

2.  Rapid synthesis of oligodeoxyribonucleotides. VII. Solid phase synthesis of oligodeoxyribonucleotides by a continuous flow phosphotriester method on a kieselguhr-polyamide support.

Authors:  M J Gait; H W Matthes; M Singh; B S Sproat; R C Titmas
Journal:  Nucleic Acids Res       Date:  1982-10-25       Impact factor: 16.971

3.  Polymer supported synthesis of oligonucleotides by a phosphotriester method.

Authors:  R Belagaje; C K Brush
Journal:  Nucleic Acids Res       Date:  1982-10-25       Impact factor: 16.971

4.  Solid phase synthesis of polynucleotides. VI. Further studies on polystyrene copolymers for the solid support.

Authors:  H Ito; Y Ike; S Ikuta; K Itakura
Journal:  Nucleic Acids Res       Date:  1982-03-11       Impact factor: 16.971

5.  A new general approach for the simultaneous chemical synthesis of large numbers of oligonucleotides: segmental solid supports.

Authors:  R Frank; W Heikens; G Heisterberg-Moutsis; H Blöcker
Journal:  Nucleic Acids Res       Date:  1983-07-11       Impact factor: 16.971

6.  Rapid synthesis of oligodeoxyribonucleotides VI. Efficient, mechanised synthesis of heptadecadeoxyribonucleotides by an improved solid phase phosphotriester route.

Authors:  M L Duckworth; M J Gait; P Goelet; G F Hong; M Singh; R C Titmas
Journal:  Nucleic Acids Res       Date:  1981-04-10       Impact factor: 16.971
  6 in total

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