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Literature DB >> 7155900

Molecular structure of (m5 dC-dG)3: the role of the methyl group on 5-methyl cytosine in stabilizing Z-DNA.

S Fujii, A H Wang, G van der Marel, J H van Boom, A Rich.

Abstract

The hexamer (m5 dC-dG)3 has been synthesized and its three-dimensional structure determined by a single crystal X-ray diffraction analysis. The structure has been refined to a final R value of 15.6% at 1.3 A resolution. The molecule forms a left-handed Z-DNA helix which is similar to the unmethylated Z-DNA structure. The presence of the methyl group has resulted in slight changes in the twist angle between successive base pairs and modification of some of the interatomic contacts. Methylation of cytosine in the C5 position is associated with a relative destabilization of the B-DNA structure and a stabilization through hydrophobic bonding of the Z-DNA structure.

Entities: Chemical

Mesh：

Substances：

Year: 1982 PMID： 7155900 PMCID： PMC327053 DOI： 10.1093/nar/10.23.7879

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

12 in total

1. Conformational analysis of the sugar ring in nucleosides and nucleotides. A new description using the concept of pseudorotation.

Authors: C Altona; M Sundaralingam
Journal: J Am Chem Soc Date: 1972-11-15 Impact factor: 15.419

2. Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).

Authors: F M Pohl; T M Jovin
Journal: J Mol Biol Date: 1972-06-28 Impact factor: 5.469

3. Molecular structure of a left-handed double helical DNA fragment at atomic resolution.

Authors: A H Wang; G J Quigley; F J Kolpak; J L Crawford; J H van Boom; G van der Marel; A Rich
Journal: Nature Date: 1979-12-13 Impact factor: 49.962

Review 4. 5-Methylcytosine in eukaryotic DNA.

Authors: M Ehrlich; R Y Wang
Journal: Science Date: 1981-06-19 Impact factor: 47.728

Review 5. DNA methylation and gene function.

Authors: A Razin; A D Riggs
Journal: Science Date: 1980-11-07 Impact factor: 47.728

Molecular structure of (m5 dC-dG)3: the role of the methyl group on 5-methyl cytosine in stabilizing Z-DNA.

1. Conformational analysis of the sugar ring in nucleosides and nucleotides. A new description using the concept of pseudorotation.

2. Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).

3. Molecular structure of a left-handed double helical DNA fragment at atomic resolution.

Review 4. 5-Methylcytosine in eukaryotic DNA.

Review 5. DNA methylation and gene function.

6. Left-handed double helical DNA: variations in the backbone conformation.

7. Antibodies to left-handed Z-DNA bind to interband regions of Drosophila polytene chromosomes.

8. Left-handed DNA helices.

9. The high salt form of poly(dG-dC).poly(dG-dC) is left-handed Z-DNA: Raman spectra of crystals and solutions.

10. Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).

1. Evidence for a new Z-type left-handed DNA helix: properties of Z(WC)-DNA.

2. CpG methylation directly inhibits binding of the human papillomavirus type 16 E2 protein to specific DNA sequences.

3. Crystal structure of d(GCGCGCG) with 5'-overhang G residues.

4. Methylation and restriction endonuclease cleavage of linear Z-DNA in the presence of hexamminecobalt (III) ions.

5. Enhanced loop DNA folding induced by thymine-CH3 group contact and perpendicular guanine-thymine interaction.

6. Hydration and recognition of methylated CpG steps in DNA.

7. Effects of base substituents on the hydration of B- and Z-DNA: correlations to the B- to Z-DNA transition.

8. Composite cylinder models of DNA: application to the electrostatics of the B-Z transition.

9. Proton NMR study of the B----Z transition of d(CGm5CG)2 and d(CGm5CGCG)2: theory and experiment.

10. Circular dichroism of poly(dG-dC) modified by the carcinogens N-methyl-4-aminoazobenzene or 4-aminobiphenyl.