Literature DB >> 8794373

CpG methylation directly inhibits binding of the human papillomavirus type 16 E2 protein to specific DNA sequences.

A Thain1, O Jenkins, A R Clarke, K Gaston.   

Abstract

CpG methylation of the human papillomavirus upstream regulatory region has previously been shown to reduce virus promoter activity. Here, we demonstrate that methylation of the CpG dinucleotides contained within the binding site of the human papillomavirus type 16 E2 protein has a direct effect on the interaction of this protein with DNA. Methylation of both CpG dinucleotides within the E2 site abolishes the binding of E2.

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Year:  1996        PMID： 8794373      PMCID： PMC190779     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  A method for the separation of GST fusion proteins from co-purifying GroEL.

Authors:  A Thain; K Gaston; O Jenkins; A R Clarke
Journal:  Trends Genet       Date:  1996-06       Impact factor: 11.639

2.  The human papillomavirus type 16 E2 transcription factor binds with low cooperativity to two flanking sites and represses the E6 promoter through displacement of Sp1 and TFIID.

Authors:  S H Tan; L E Leong; P A Walker; H U Bernard
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103

3.  Molecular structure of (m5 dC-dG)3: the role of the methyl group on 5-methyl cytosine in stabilizing Z-DNA.

Authors:  S Fujii; A H Wang; G van der Marel; J H van Boom; A Rich
Journal:  Nucleic Acids Res       Date:  1982-12-11       Impact factor: 16.971

4.  Structure and transcription of human papillomavirus sequences in cervical carcinoma cells.

Authors:  E Schwarz; U K Freese; L Gissmann; W Mayer; B Roggenbuck; A Stremlau; H zur Hausen
Journal:  Nature       Date:  1985 Mar 7-13       Impact factor: 49.962

5.  Binding of the human papillomavirus E1 origin-recognition protein is regulated through complex formation with the E2 enhancer-binding protein.

Authors:  M G Frattini; L A Laimins
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

6.  Uneven distribution of methylation sites within the human papillomavirus la genome: possible relevance to viral gene expression.

Authors:  T S Burnett; J P Sleeman
Journal:  Nucleic Acids Res       Date:  1984-12-11       Impact factor: 16.971

7.  CpG methylation has differential effects on the binding of YY1 and ETS proteins to the bi-directional promoter of the Surf-1 and Surf-2 genes.

Authors:  K Gaston; M Fried
Journal:  Nucleic Acids Res       Date:  1995-03-25       Impact factor: 16.971

8.  The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumours.

Authors:  M Dürst; A Kleinheinz; M Hotz; L Gissmann
Journal:  J Gen Virol       Date:  1985-07       Impact factor: 3.891

9.  Shope papilloma virus DNA is extensively methylated in non-virus-producing neoplasms.

Authors:  F O Wettstein; J G Stevens
Journal:  Virology       Date:  1983-04-30       Impact factor: 3.616

10.  Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes.

Authors:  A Schneider-Gädicke; E Schwarz
Journal:  EMBO J       Date:  1986-09       Impact factor: 11.598
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  41 in total

1.  Tissue-specific silencing of a transgene in rice.

Authors:  A Klöti; X He; I Potrykus; T Hohn; J Fütterer
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-19       Impact factor: 11.205

Review 2.  Papillomavirus genome structure, expression, and post-transcriptional regulation.

Authors:  Zhi-Ming Zheng; Carl C Baker
Journal:  Front Biosci       Date:  2006-09-01

Review 3.  Replication and partitioning of papillomavirus genomes.

Authors:  Alison A McBride
Journal:  Adv Virus Res       Date:  2008       Impact factor: 9.937

4.  Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma.

Authors:  Cai Guo Ye; George G Chen; Rocky L K Ho; Juanita L Merchant; Ming-Liang He; Paul B S Lai
Journal:  Biochim Biophys Acta       Date:  2013-08-13

Review 5.  Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions.

Authors:  Renske D M Steenbergen; Peter J F Snijders; Daniëlle A M Heideman; Chris J L M Meijer
Journal:  Nat Rev Cancer       Date:  2014-06       Impact factor: 60.716

6.  Folate and vitamin B12 may play a critical role in lowering the HPV 16 methylation-associated risk of developing higher grades of CIN.

Authors:  Chandrika J Piyathilake; Maurizio Macaluso; Michelle M Chambers; Suguna Badiga; Nuzhat R Siddiqui; Walter C Bell; Jeffrey C Edberg; Edward E Partridge; Ronald D Alvarez; Gary L Johanning
Journal:  Cancer Prev Res (Phila)       Date:  2014-08-21

7.  Identification and analysis of papillomavirus E2 protein binding sites in the human genome.

Authors:  Liisi Võsa; Aleksander Sudakov; Maido Remm; Mart Ustav; Reet Kurg
Journal:  J Virol       Date:  2011-10-26       Impact factor: 5.103

8.  Orientation of a novel DNA binding site affects human papillomavirus-mediated transcription and replication.

Authors:  C D Newhouse; S J Silverstein
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

9.  Methylation of human papillomavirus Type 16 CpG sites at E2-binding site 1 (E2BS1), E2BS2, and the Sp1-binding site in cervical cancer samples as determined by high-resolution melting analysis-PCR.

Authors:  Elise Jacquin; Alice Baraquin; Rajeev Ramanah; Xavier Carcopino; Adrien Morel; Séverine Valmary-Degano; Ignacio G Bravo; Silvia de Sanjosé; Didier Riethmuller; Christiane Mougin; Jean-Luc Prétet
Journal:  J Clin Microbiol       Date:  2013-07-17       Impact factor: 5.948

10.  Human papillomaviruses: research priorities for the next decade.

Authors:  Erika Langsfeld; Laimonis A Laimins
Journal:  Trends Cancer       Date:  2016-05
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