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Literature DB >> 7301594

The high salt form of poly(dG-dC).poly(dG-dC) is left-handed Z-DNA: Raman spectra of crystals and solutions.

T J Thamann, R C Lord, A H Wang, A Rich.

Abstract

The laser-Raman spectra of crystalline d(CpGpCpGpCpG) and of aqueous poly(dG-dC).poly(dG-dC) in high salt (4M NaCl) and low salt (0.1M NaCl) solutions have been measured and compared. The spectra of the crystal and the high-salt solution show a striking congruence, which indicates clearly that the high-salt form of the aqueous polymer has the left-handed Z-DNA structure of the crystalline oligomer. These two spectra differ substantially from that of the low-salt form of the polymer, which has been found previously to have spectral characteristics of the B-form of DNA. The high salt spectrum shows a unique line due to guanine residues at 625 cm-1 which should be useful for qualitative and possibly quantitative assessment of the amount of Z-structure present in a sample of DNA.

Entities: Chemical

Mesh：

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Year: 1981 PMID： 7301594 PMCID： PMC327531 DOI： 10.1093/nar/9.20.5443

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

7 in total

1. Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).

Authors: F M Pohl; T M Jovin
Journal: J Mol Biol Date: 1972-06-28 Impact factor: 5.469

2. Molecular structure of a left-handed double helical DNA fragment at atomic resolution.

Authors: A H Wang; G J Quigley; F J Kolpak; J L Crawford; J H van Boom; G van der Marel; A Rich
Journal: Nature Date: 1979-12-13 Impact factor: 49.962

3. Conformational stability of alternating d (CG) oligomers in high salt solution.

Authors: F Quadrifoglio; G Manzini; M Vasser; K Dinkelspiel; R Crea
Journal: Nucleic Acids Res Date: 1981-05-11 Impact factor: 16.971

4. The tetramer d(CpGpCpG) crystallizes as a left-handed double helix.

Authors: J L Crawford; F J Kolpak; A H Wang; G J Quigley; J H van Boom; G van der Marel; A Rich
Journal: Proc Natl Acad Sci U S A Date: 1980-07 Impact factor: 11.205

5. "Alternating B-DNA" conformation for the oligo(dG-dC) duplex in high-salt solution.

Authors: D J Patel; L L Canuel; F M Pohl
Journal: Proc Natl Acad Sci U S A Date: 1979-06 Impact factor: 11.205

6. Ethidium bromide as a cooperative effector of a DNA structure.

Authors: F M Pohl; T M Jovin; W Baehr; J J Holbrook
Journal: Proc Natl Acad Sci U S A Date: 1972-12 Impact factor: 11.205

7. Left-handed double helical DNA: variations in the backbone conformation.

Authors: A J Wang; G J Quigley; F J Kolpak; G van der Marel; J H van Boom; A Rich
Journal: Science Date: 1981-01-09 Impact factor: 47.728

7 in total

54 in total

1. Reversible B/Z-DNA transition under the low salt condition and non-B-form polydApolydT selectivity by a cubane-like europium-L-aspartic acid complex.

Authors: Haiyuan Zhang; Haijia Yu; Jinsong Ren; Xiaogang Qu
Journal: Biophys J Date: 2006-02-10 Impact factor: 4.033

2. Junction between Z and B conformations in a DNA restriction fragment: evaluation by Raman spectroscopy.

Authors: R M Wartell; J Klysik; W Hillen; R D Wells
Journal: Proc Natl Acad Sci U S A Date: 1982-04 Impact factor: 11.205

3. Normal coordinate analysis of 5'-dGMP and its deuterated derivatives. A calculated approach to designate the guanine-residue vibration modes in B and Z forms of DNA.

Authors: M Ghomi; E Taillandier
Journal: Eur Biophys J Date: 1985 Impact factor: 1.733

The high salt form of poly(dG-dC).poly(dG-dC) is left-handed Z-DNA: Raman spectra of crystals and solutions.

1. Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).

2. Molecular structure of a left-handed double helical DNA fragment at atomic resolution.

3. Conformational stability of alternating d (CG) oligomers in high salt solution.

4. The tetramer d(CpGpCpG) crystallizes as a left-handed double helix.

5. "Alternating B-DNA" conformation for the oligo(dG-dC) duplex in high-salt solution.

6. Ethidium bromide as a cooperative effector of a DNA structure.

7. Left-handed double helical DNA: variations in the backbone conformation.

1. Reversible B/Z-DNA transition under the low salt condition and non-B-form polydApolydT selectivity by a cubane-like europium-L-aspartic acid complex.

2. Junction between Z and B conformations in a DNA restriction fragment: evaluation by Raman spectroscopy.

3. Normal coordinate analysis of 5'-dGMP and its deuterated derivatives. A calculated approach to designate the guanine-residue vibration modes in B and Z forms of DNA.

4. The Raman spectra of left-handed DNA oligomers incorporating adenine-thymine base pairs+.

5. Right-handed and left-handed DNA: studies of B- and Z-DNA by using proton nuclear Overhauser effect and P NMR.

6. Lack of Z-DNA conformation in mitomycin-modified polynucleotides having inverted circular dichroism.

7. Right-handed and left-handed helices of poly(dA-dC) X (dG-dT).

8. Z form of poly d(A-C).poly d(G-T) in solution studied by Raman spectroscopy.

9. Daunomycin inhibits the B leads to Z transition in poly d(G-C).

10. Stabilization of (dG-dC)n.(dG-dC)n in the Z conformation by a crosslinking reaction.