Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Moments of physiological transit time distributions and the time course of drug disposition in the body.

Literature DB >> 7153675

Moments of physiological transit time distributions and the time course of drug disposition in the body.

Abstract

Characterizing the tissue distribution kinetics of drugs by physiological and physico-chemical parameters and using a circulatory model the time course of blood concentration after intravenous injection is predicted for linear pharmacokinetic systems. The interrelationships between the first three (zero to second) moments of the distribution functions of organ transfer times, circulation times and residence times of drug molecules in the body are described. Utilizing literature data the model is applied to the analysis of lidocain kinetics in humans.

Entities: Chemical Species

Mesh：

Substances：

Year: 1982 PMID： 7153675 DOI： 10.1007/bf00275690

Source DB: PubMed Journal: J Math Biol ISSN： 0303-6812 Impact factor: 2.259

23 in total

Review 1. Applications of a recirculatory stochastic pharmacokinetic model: limitations of compartmental models.

Authors: D P Vaughan; I Hope
Journal: J Pharmacokinet Biopharm Date: 1979-04

2. A unified theory for estimation of cardiac output, volumes of distribution and renal clearance from indicator dilution curves.

Authors: L D Homer; A Small
Journal: J Theor Biol Date: 1977-02-07 Impact factor: 2.691

4. Residence time dispersion as a general measure of drug distribution kinetics: estimation and physiological interpretation.

Authors: Michael Weiss
Journal: Pharm Res Date: 2007-05-18 Impact factor: 4.200

5. Comparison and critique of two models for regional drug delivery.

Authors: R A Siegel; R D MacGregor; C A Hunt
Journal: J Pharmacokinet Biopharm Date: 1991-06

6. Mean time parameters for generalized physiological flow models (semihomogeneous linear systems).

Authors: D Verotta; L B Sheiner; S L Beal
Journal: J Pharmacokinet Biopharm Date: 1991-06

7. Tissue distribution kinetics as determinant of transit time dispersion of drugs in organs: application of a stochastic model to the rat hindlimb.

Authors: M Weiss; M S Roberts
Journal: J Pharmacokinet Biopharm Date: 1996-04

8. Two-compartment dispersion model for analysis of organ perfusion system of drugs by fast inverse Laplace transform (FILT).

Authors: Y Yano; K Yamaoka; Y Aoyama; H Tanaka
Journal: J Pharmacokinet Biopharm Date: 1989-04

9. A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

Authors: M S Roberts; M Rowland
Journal: J Pharmacokinet Biopharm Date: 1986-06

10. Kinetic analysis of the drug permeation process across the intestinal epithelium.

Authors: S Yamashita; M Yoshida; Y Taki; T Sakane; T Nadai
Journal: Pharm Res Date: 1994-11 Impact factor: 4.200

Moments of physiological transit time distributions and the time course of drug disposition in the body.

Review 1. Applications of a recirculatory stochastic pharmacokinetic model: limitations of compartmental models.

2. A unified theory for estimation of cardiac output, volumes of distribution and renal clearance from indicator dilution curves.

3. A linear recirculation model for drug disposition.

4. Capillary exchange modeling. Barrier-limited and flow-limited distribution.

5. Pharmacokinetic aspects of intravenous regional anesthesia.

6. Hepatic clearance of local anesthetics in man.

7. Lidocaine disposition kinetics in monkey and man. I. Prediction by a perfusion model.

8. Statistical moments in pharmacokinetics.

9. Residence time and accumulation of drugs in the body.

10. Stochastic models for tracer experiments in the circulation. 3. The lumped catenary system.

1. The relevance of residence time theory to pharmacokinetics.

2. Statistical moments and disposition parameters in a local perfusion system under mammillary nonequilibrium condition.

Review 3. Mean time parameters in pharmacokinetics. Definition, computation and clinical implications (Part II).