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Literature DB >> 731417

Statistical moments in pharmacokinetics.

Abstract

Statistical moments are parameters that describe the characteristics of the time courses of plasma concentration (area, mean residence time, and variance of residence time) and of the urinary excretion rate that follow administration of a single dose of a drug. The relationship between the moments of a time-course curve and pharmacokinetic profiles of drug disposition, i.e., absorption, distribution, metabolism, and excretion, is described. The moments are related to the extent and rate of bioavailability, and it is shown that they can be effectively applied to the deconvolution operation.

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Year: 1978 PMID： 731417 DOI： 10.1007/bf01062109

Source DB: PubMed Journal: J Pharmacokinet Biopharm ISSN： 0090-466X

25 in total

1. KINETIC ANALYSIS OF BLOOD LEVELS AND URINARY EXCRETION IN THE ABSORPTIVE PHASE AFTER SINGLE DOSES OF DRUG.

Authors: J G WAGNER; E NELSON
Journal: J Pharm Sci Date: 1964-11 Impact factor: 3.534

2. Theorems on linear systems.

Authors: J Z HEARON
Journal: Ann N Y Acad Sci Date: 1963-05-10 Impact factor: 5.691

3. [Cephacetrile (C 36278-Ba), a new antibiotic of the cephalosporin group. Pharmacokinetics and clinical investigation].

Authors: P N Maurice; W Riess; A Welke; K Amson
Journal: Arzneimittelforschung Date: 1974-09

4. Contribution to the pharmacokinetics of a new cephalosporin derivative.

Authors: K Dvorácek; Z Modr; O Schmidt; A Necásková
Journal: Arzneimittelforschung Date: 1974-09

5. Drug input optimization: bioavailability-effected time-optimal control of multiple, simultaneous, pharmacological effects and their interrelationships.

Authors: V F Smolen; B D Turrie; W A Weigand
Journal: J Pharm Sci Date: 1972-12 Impact factor: 3.534

6. Pharmacokinetic analysis on the disappearance of ethoxybenzamide from plasma. Statistical treatment of data of two compartmental model by a digital computer.

Authors: H Nogami; M Hanano; S Awazu; H H Moon
Journal: Chem Pharm Bull (Tokyo) Date: 1969-10 Impact factor: 1.645

7. Pharmacokinetics of methyldopa in man.

Authors: K C Kwan; E L Foltz; G O Breault; J E Baer; J A Totaro
Journal: J Pharmacol Exp Ther Date: 1976-08 Impact factor: 4.030

8. Estimation of volume of distribution and half-life of a compound after rapid intravenous injection.

Authors: J G Wagner; J I Northam
Journal: J Pharm Sci Date: 1967-04 Impact factor: 3.534

9. Absorption, metabolism, and excretion of 5-methylpyrazole-3-carboxylic acid in the rat, dog, and human.

Authors: D L Smith; J G Wagner; G C Gerritsen
Journal: J Pharm Sci Date: 1967-09 Impact factor: 3.534

10. Mathematical model of sustained-release preparations and its analysis.

Authors: E K Thiemer; S P Eriksen
Journal: J Pharm Sci Date: 1966-11 Impact factor: 3.534

239 in total

1. Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose.

Authors: N Isoherranen; E Lavy; S Soback
Journal: Antimicrob Agents Chemother Date: 2000-06 Impact factor: 5.191

2. Some pharmacokinetic parameters and dosage regimens for a long-acting formulation of oxytetracycline in 6- to 8-month-old male calves.

Authors: R Kumar; J K Malik
Journal: Vet Res Commun Date: 1998-12 Impact factor: 2.459

3. Quantitative evaluation of capacity-limited hepatobiliary transport based on hepatocellular diffusion model by MULTI(FEM).

Authors: M Higashimori; K Yamaoka; S Fujitani; T Nakagawa
Journal: J Pharmacokinet Pharmacodyn Date: 2001-10 Impact factor: 2.745

Statistical moments in pharmacokinetics.

1. KINETIC ANALYSIS OF BLOOD LEVELS AND URINARY EXCRETION IN THE ABSORPTIVE PHASE AFTER SINGLE DOSES OF DRUG.

2. Theorems on linear systems.

3. [Cephacetrile (C 36278-Ba), a new antibiotic of the cephalosporin group. Pharmacokinetics and clinical investigation].

4. Contribution to the pharmacokinetics of a new cephalosporin derivative.

5. Drug input optimization: bioavailability-effected time-optimal control of multiple, simultaneous, pharmacological effects and their interrelationships.

6. Pharmacokinetic analysis on the disappearance of ethoxybenzamide from plasma. Statistical treatment of data of two compartmental model by a digital computer.

7. Pharmacokinetics of methyldopa in man.

8. Estimation of volume of distribution and half-life of a compound after rapid intravenous injection.

9. Absorption, metabolism, and excretion of 5-methylpyrazole-3-carboxylic acid in the rat, dog, and human.

10. Mathematical model of sustained-release preparations and its analysis.

1. Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose.

2. Some pharmacokinetic parameters and dosage regimens for a long-acting formulation of oxytetracycline in 6- to 8-month-old male calves.

3. Quantitative evaluation of capacity-limited hepatobiliary transport based on hepatocellular diffusion model by MULTI(FEM).

4. Bioavailability of praziquantel increases with concomitant administration of food.

5. The mean dissolution time depends on the dose/solubility ratio.

6. Plasma level monitoring of nasal salmon calcitonin in the rat by a heterogeneous two-site enzyme immunoassay.

7. Kinetic analysis of the drug permeation process across the intestinal epithelium.

8. The analysis and disposition of imipramine and its active metabolites in man.

9. Structure-pharmacokinetic relationships in a series of valpromide derivatives with antiepileptic activity.

10. Cerebral and blood pharmacokinetics of imipramine and its active metabolites in the pregnant rat.