Literature DB >> 7216555

Residence time and accumulation of drugs in the body.

M Weiss.   

Abstract

This investigation presents a simple and clinically useful theory of drug accumulation based on the mean residence time of drug molecules in the plasma compartment. The parameters decay fraction and accumulation factor, defined in terms of average steady-state amount in the body, are used to characterize the pharmacokinetics of multiple dosing. These parameters are calculated for digoxin and digitoxin.

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Year:  1981        PMID： 7216555

Source DB:  PubMed          Journal:  Int J Clin Pharmacol Ther Toxicol        ISSN： 0174-4879


  12 in total

1.  The relevance of residence time theory to pharmacokinetics.

Authors:  M Weiss
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

Review 2.  Mean time parameters in pharmacokinetics. Definition, computation and clinical implications (Part II).

Authors:  P Veng-Pedersen
Journal:  Clin Pharmacokinet       Date:  1989-12       Impact factor: 6.447

3.  Constant-rate intravenous infusion methods for estimating steady-state volumes of distribution and mean residence times in the body for drugs undergoing reversible metabolism.

Authors:  H Cheng; W J Jusko
Journal:  Pharm Res       Date:  1990-06       Impact factor: 4.200

4.  General treatment of mean residence time, clearance, and volume parameters in linear mammillary models with elimination from any compartment.

Authors:  E Nakashima; L Z Benet
Journal:  J Pharmacokinet Biopharm       Date:  1988-10

5.  Linear and nonlinear system approaches in pharmacokinetics: how much do they have to offer? I. General considerations.

Authors:  P Veng-Pedersen
Journal:  J Pharmacokinet Biopharm       Date:  1988-08

6.  Use of gamma distributed residence times in pharmacokinetics.

Authors:  M Weiss
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

7.  Model-independent assessment of accumulation kinetics based on moments of drug disposition curves.

Authors:  M Weiss
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

8.  Definition of pharmacokinetic parameters: influence of the sampling site.

Authors:  M Weiss
Journal:  J Pharmacokinet Biopharm       Date:  1984-04

9.  Modelling of initial distribution of drugs following intravenous bolus injection.

Authors:  M Weiss
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

10.  Hemodynamic influences upon the variance of disposition residence time distribution of drugs.

Authors:  M Weiss
Journal:  J Pharmacokinet Biopharm       Date:  1983-02
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