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Literature DB >> 458553

A linear recirculation model for drug disposition.

Abstract

A new approach to the modeling of drug disposition is described. Disposition is regarded as the result of repetitive passes of the drug around the circulation. Mathematical analysis of experimental blood concentration data yields an expression describing the kinetics of a single pass through the tissues. In physicochemical terms the single-pass behavior depends to a large extent on the interaction of the drug with individual tissues, which greatly simplifies interpretation. The method may reveal features of disposition not apparent from experimental blood concentration data.

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Year: 1979 PMID： 458553 DOI： 10.1007/bf01059445

Source DB: PubMed Journal: J Pharmacokinet Biopharm ISSN： 0090-466X

7 in total

1. Pharmacokinetics of digoxin in normal subjects after intravenous bolus and infusion doses.

Authors: J R Koup; D J Greenblatt; W J Jusko; T W Smith; J Koch-Weser
Journal: J Pharmacokinet Biopharm Date: 1975-06

2. The pharmacokinetics of propylthiouracil.

Authors: J Kampmann; L Skovsted
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1974-11

3. Transfer times across the human body.

Authors: C Waterhouse; J Keilson
Journal: Bull Math Biophys Date: 1972-03

4. Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment.

Authors: S Riegelman; J C Loo; M Rowland
Journal: J Pharm Sci Date: 1968-01 Impact factor: 3.534

5. Linear systems analysis in pharmacokinetics.

Authors: D J Cutler
Journal: J Pharmacokinet Biopharm Date: 1978-06

6. Physiologically based pharmacokinetic model for digoxin disposition in dogs and its preliminary application to humans.

Authors: L I Harrison; M Gibaldi
Journal: J Pharm Sci Date: 1977-12 Impact factor: 3.534

7. Pharmocokinetics of hexobarbital in man after intravenous infusion.

Authors: D D Breimer; C Honhoff; W Zilly; E Richter; J M van Rossum
Journal: J Pharmacokinet Biopharm Date: 1975-02

7 in total

29 in total

10. Pharmacokinetic differentiation of drug candidates using system analysis and physiological-based modelling. Comparison of C.E.R.A. and erythropoietin.

Authors: Peter Veng-Pedersen; Kevin J Freise; Robert L Schmidt; John A Widness
Journal: J Pharm Pharmacol Date: 2008-10 Impact factor: 3.765

A linear recirculation model for drug disposition.

1. Pharmacokinetics of digoxin in normal subjects after intravenous bolus and infusion doses.

2. The pharmacokinetics of propylthiouracil.

3. Transfer times across the human body.

4. Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment.

5. Linear systems analysis in pharmacokinetics.

6. Physiologically based pharmacokinetic model for digoxin disposition in dogs and its preliminary application to humans.

7. Pharmocokinetics of hexobarbital in man after intravenous infusion.

1. Dynamics of drug distribution. I. Role of the second and third curve moments.

2. Statistical moments and disposition parameters in a local perfusion system under mammillary nonequilibrium condition.

Review 3. Noncompartmental versus compartmental modelling in clinical pharmacokinetics.

Review 4. Systems dynamics in clinical pharmacokinetics. An introduction.

Review 5. Mean time parameters in pharmacokinetics. Definition, computation and clinical implications (Part II).

Review 6. Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts.

7. An approximate model-independent method to maintain constant plasma levels of intravenous drugs.

8. Application of a linear recirculation model to drug targeting.

9. Exponential tails of drug disposition curves: reality or appearance?

10. Pharmacokinetic differentiation of drug candidates using system analysis and physiological-based modelling. Comparison of C.E.R.A. and erythropoietin.