Literature DB >> 7144057

Renal metabolism of corticosteroid hormones.

K Hierholzer, I Lichtenstein, H Siebe, D Tsiakiras, I Witt.   

Abstract

IK and STF from male and female rats have been used to study in vitro the renal metabolism of B. in male rat tissue four lipid soluble metabolites (I-IV) have been found, I + II being more polar and III + IV being less polar than B. I and II have been identified as 11-dehydro-20-hydroxy-B and 20-hydroxy-B. The structure of III and IV remains to be determined. Renal tissue from female rats produced predominantly III indicating sexual variations of steroid metabolism in kidneys.--The literature has been reviewed which documents that the kidneys in addition to B metabolize A, cortisol, progesterone and other corticosteroids.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 7144057     DOI： 10.1007/BF01715842

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  32 in total

1.  CONJUGATION OF 1,2-3H-ALDOSTERONE IN HUMAN LIVER AND KIDNEYS AND RENAL EXTRACTION OF ALDOSTERONE AND LABELED CONJUGATES FROM BLOOD PLASMA.

Authors:  J A LUETSCHER; E W HANCOCK; C A CAMARGO; A J DOWDY; G W NOKES
Journal:  J Clin Endocrinol Metab       Date:  1965-05       Impact factor: 5.958

2.  The reduction of the C-20 carbonyl group of tetrahydrocortisone by kidney homogenates.

Authors:  C DE COURCY
Journal:  J Biol Chem       Date:  1957-12       Impact factor: 5.157

3.  Species differences in adrenocortical secretion.

Authors:  I E BUSH
Journal:  J Endocrinol       Date:  1953-01       Impact factor: 4.286

4.  Irreversible neonatal differentiation of corticosterone metabolism in rats in vivo.

Authors:  R J Begue; J A Gustafsson; S A Gustafsson
Journal:  Eur J Biochem       Date:  1973-12-17

5.  Effect of androgens and anabolic steroids on the plasma disappearance curve and the distribution of (1,2- 3 H) corticosterone in the rat.

Authors:  O Linèt; P Lomen
Journal:  Acta Endocrinol (Copenh)       Date:  1971-10

6.  Conjugation of aldosterone by bovine and mouse liver and kidney.

Authors:  N M Panagiotis; D L Berliner
Journal:  Nature       Date:  1965-06-19       Impact factor: 49.962

7.  Sexual differences in hepatic metabolism and intracellular distribution of corticosterone studied by pulse labeling with (1,2,6,7-3H)corticosterone.

Authors:  J Carlstedt-Duke; J A Gustafsson; S A Gustafsson
Journal:  Biochemistry       Date:  1975-02-11       Impact factor: 3.162

8.  Deoxycorticosterone biosynthesis in human kidney: potential for formation of a potent mineralocorticosteroid in its site of action.

Authors:  C A Winkel; E R Simpson; L Milewich; P C MacDonald
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

9.  Metabolism of 20beta-hydroxy-4-pregnen-3-one in uterine tissue of non-pregnant rats in vitro.

Authors:  B P Lisboa; M Holtermann
Journal:  Acta Endocrinol (Copenh)       Date:  1976-11

10.  Cortisol metabolism and excretion in the isolated perfused rat kidney.

Authors:  G Reach; H Nakane; Y Nakane; C Auzan; P Corvol
Journal:  Steroids       Date:  1977-11       Impact factor: 2.668
View more
  6 in total

1.  Corticosteroid metabolism in isolated rat kidney in vitro. III. Structure analysis of lipid soluble metabolites of corticosterone.

Authors:  G A Hoyer; D Tsiakiras; H Siebe; K Hierholzer
Journal:  Pflugers Arch       Date:  1984-04       Impact factor: 3.657

2.  Corticosteroid metabolism in isolated rat kidney in vitro. I. Formation of lipid soluble metabolites from corticosterone (B) in renal tissue from male rats.

Authors:  K Hierholzer; M Schöneshöfer; H Siebe; D Tsiakiras; P Weskamp
Journal:  Pflugers Arch       Date:  1984-04       Impact factor: 3.657

3.  Renal metabolism of corticosteroid hormones.

Authors:  K Hierholzer; I Lichtenstein; H Siebe; D Tsiakiras; I Witt
Journal:  Klin Wochenschr       Date:  1982-09-15

4.  Bile acids and their amidates inhibit 11 beta-hydroxysteroid dehydrogenase obtained from rat kidney.

Authors:  F H Perschel; H Bühler; K Hierholzer
Journal:  Pflugers Arch       Date:  1991-07       Impact factor: 3.657

5.  Corticosteroid metabolism in rat kidney in vitro. IV. Subcellular, sites of 11 beta-hydroxysteroid dehydrogenase activity.

Authors:  N Kobayashi; W Schulz; K Hierholzer
Journal:  Pflugers Arch       Date:  1987-01       Impact factor: 3.657

6.  Aldosterone metabolism in rat renal tissue in vitro. Formation of lipid soluble metabolites.

Authors:  D l'Allemand; H Siebe; D Tsiakiras; G A Hoyer; P Vecsei; K Hierholzer
Journal:  Pflugers Arch       Date:  1988-05       Impact factor: 3.657
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.