Literature DB >> 611630

Cortisol metabolism and excretion in the isolated perfused rat kidney.

G Reach, H Nakane, Y Nakane, C Auzan, P Corvol.   

Abstract

The isolated perfused rat kidney allows a simultaneous kinetic study of both the renal metabolism and the urinary excretion of cortisol and its metabolites in the rat. In this system, cortisol was completely metabolized within 120 minutes. The main renal metabolites of cortisol (cortisone, 20 reduced cortisol and 20 reduced cortisone) were found in the recirculating perfusate and in urine. The formation of these metabolites was quantitatively evaluated and compared to a theoretical model.

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Year:  1977        PMID： 611630     DOI： 10.1016/0039-128x(77)90052-6

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  6 in total

1.  Sodium loading raises urinary cortisol in man.

Authors:  G Wambach; C Bleienheuft; G Bönner
Journal:  J Endocrinol Invest       Date:  1986-06       Impact factor: 4.256

2.  Corticosteroid metabolism in isolated rat kidney in vitro. II. Sex dependency of metabolism and formation of 11-dehydro-corticosterone.

Authors:  H Siebe; D Tsiakiras; K Hierholzer
Journal:  Pflugers Arch       Date:  1984-04       Impact factor: 3.657

3.  Corticosteroid metabolism in isolated rat kidney in vitro. I. Formation of lipid soluble metabolites from corticosterone (B) in renal tissue from male rats.

Authors:  K Hierholzer; M Schöneshöfer; H Siebe; D Tsiakiras; P Weskamp
Journal:  Pflugers Arch       Date:  1984-04       Impact factor: 3.657

4.  Renal metabolism of corticosteroid hormones.

Authors:  K Hierholzer; I Lichtenstein; H Siebe; D Tsiakiras; I Witt
Journal:  Klin Wochenschr       Date:  1982-09-15

5.  Reference values and physiological characterization of a specific isolated pig kidney perfusion model.

Authors:  Volker Unger; Christian Grosse-Siestrup; Claudia Fehrenberg; Axel Fischer; Michael Meissler; David A Groneberg
Journal:  J Occup Med Toxicol       Date:  2007-01-29       Impact factor: 2.646

6.  The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome.

Authors:  Minghan Wang
Journal:  Nutr Metab (Lond)       Date:  2005-02-02       Impact factor: 4.169
  6 in total

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