Literature DB >> 7126171

Effect of inhibition of fatty acid oxidation on neonatal liver carnitine content.

S C Frost, M A Wells.   

Abstract

The hypoglycaemic agent 2-tetradecylglycidic acid (compound McN-3802) caused an increase in total liver carnitine content, this being due primarily to an increase in the free carnitine pool. In the neonatal animal, this may represent a mechanism to overcome the inhibitory effect of fatty acid oxidation by the drug.

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Year:  1982        PMID： 7126171      PMCID： PMC1158431          DOI： 10.1042/bj2040861

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  21 in total

1.  Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver.

Authors:  F J Ballard; R W Hanson
Journal:  Biochem J       Date:  1967-09       Impact factor: 3.857

2.  An improved and simplified radioisotopic assay for the determination of free and esterified carnitine.

Authors:  J D McGarry; D W Foster
Journal:  J Lipid Res       Date:  1976-05       Impact factor: 5.922

3.  A comparison of the utilization of medium and long-chain fatty acids for oxidation and ketogenesis in the suckling rat: in vivo and in vitro studies.

Authors:  S C Frost; M A Wells
Journal:  Arch Biochem Biophys       Date:  1981-10-15       Impact factor: 4.013

4.  Effect of the oral hypoglycemic agent 2-tetradecylglycidic acid on fatty acid oxidation in suckling rats in vivo and in perfused liver.

Authors:  S C Frost; M A Wells
Journal:  Arch Biochem Biophys       Date:  1981-10-15       Impact factor: 4.013

5.  Relationship between ketogenesis and gluconeogenesis in isolated hepatocytes from newborn rats.

Authors:  P Ferré; P Satabin; L El Manoubi; S Callikan; J Girard
Journal:  Biochem J       Date:  1981-11-15       Impact factor: 3.857

6.  Perinatal changes in plasma carnitine levels in 4 species of mammal.

Authors:  P Hahn; D Seccombe; M E Towell
Journal:  Experientia       Date:  1980-12-15

7.  Carnitine and derivatives in rat tissues.

Authors:  D J Pearson; P K Tubbs
Journal:  Biochem J       Date:  1967-12       Impact factor: 3.857

8.  The effects of inhibition of fatty acid oxidation in suckling newborn rats.

Authors:  J P Pégorier; P Ferré; J Girard
Journal:  Biochem J       Date:  1977-09-15       Impact factor: 3.857

9.  The effect of acute and prolonged ethanol treatment on the contents of coenzyme A, carnitine and their derivatives in rat liver.

Authors:  J Kondrup; N Grunnet
Journal:  Biochem J       Date:  1973-03       Impact factor: 3.857

10.  The role of the kidney in the biosynthesis of carnitine in the rat.

Authors:  A L Carter; R Frenkel
Journal:  J Biol Chem       Date:  1979-11-10       Impact factor: 5.157
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