Literature DB >> 7124730

Heritable fragile sites on human chromosomes. IX. Population cytogenetics and segregation analysis of the BrdU-requiring fragile site at 10q25.

G R Sutherland.   

Abstract

The frequencies of the bromodeoxyuridine (BrdU)-requiring fragile site at 10q25 in 1,026 unselected neonates, 901 patients referred for chromosome studies, and 87 institutionalized retardates were not significantly different from each other. The gene frequency was .013, and the population was in Hardy-Weinberg equilibrium. Segregation analysis confirmed that the fragile site followed codominant inheritance. This fragile site and its nonfragile allelomorph can be considered to constitute the first true chromosomal polymorphism to be described in man.

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Year:  1982        PMID： 7124730      PMCID： PMC1685438     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  5 in total

1.  The genetics of polymorphism in the Lepidoptera.

Authors:  E B FORD
Journal:  Adv Genet       Date:  1953       Impact factor: 1.944

2.  Heritable fragile sites and lymphocyte culture medium containing BrdU.

Authors:  J M Scheres; T W Hustinx
Journal:  Am J Hum Genet       Date:  1980-07       Impact factor: 11.025

3.  Heritable fragile sites on human chromosomes. VIII. Preliminary population cytogenetic data on the folic-acid-sensitive fragile sites.

Authors:  G R Sutherland
Journal:  Am J Hum Genet       Date:  1982-05       Impact factor: 11.025

4.  Heritable fragile sites on human chromosomes. VII. Children homozygous for the BrdU-requiring fra(10)(q25) are phenotypically normal.

Authors:  G R Sutherland
Journal:  Am J Hum Genet       Date:  1981-11       Impact factor: 11.025

5.  Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression.

Authors:  G R Sutherland; E Baker; R S Seshadri
Journal:  Am J Hum Genet       Date:  1980-07       Impact factor: 11.025
  5 in total
  10 in total

1.  Fragile site (16) (q22). III. Segregation analysis.

Authors:  B Müller; W Feichtinger; C Bonaïti-Pellié; M Schmid
Journal:  Hum Genet       Date:  1992-08       Impact factor: 4.132

2.  Population cytogenetics of rare fragile sites in Japan.

Authors:  E Takahashi; T Hori; M Murata
Journal:  Hum Genet       Date:  1988-02       Impact factor: 4.132

3.  Population cytogenetics of folate-sensitive fragile sites. II. Autosomal rare fragile sites.

Authors:  M Kähkönen; C Tengström; T Alitalo; R Matilainen; M Kaski; E Airaksinen
Journal:  Hum Genet       Date:  1989-04       Impact factor: 4.132

4.  The fragile site (16) (q22). I. Induction by AT-specific DNA-ligands and population frequency.

Authors:  M Schmid; W Feichtinger; A Jessberger; J Köhler; R Lange
Journal:  Hum Genet       Date:  1986-09       Impact factor: 4.132

5.  Rare, polymorphic, and common fragile sites: a classification.

Authors:  F Hecht
Journal:  Hum Genet       Date:  1986-10       Impact factor: 4.132

6.  The fragile site (17)(p12): induction by AT-specific DNA-ligands and population cytogenetics.

Authors:  M Schmid; W Feichtinger; C Deubelbeiss; E Weller
Journal:  Hum Genet       Date:  1987-10       Impact factor: 4.132

7.  Genomic and epigenomic instability, fragile sites, schizophrenia and autism.

Authors:  Cassandra L Smith; Andrew Bolton; Giang Nguyen
Journal:  Curr Genomics       Date:  2010-09       Impact factor: 2.236

8.  Segregation analysis of rare autosomal fragile sites.

Authors:  S L Sherman; G R Sutherland
Journal:  Hum Genet       Date:  1986-02       Impact factor: 4.132

9.  Heritable fragile sites on human chromosomes. XI. Factors affecting expression of fragile sites at 10q25, 16q22, and 17p12.

Authors:  G R Sutherland; P B Jacky; E G Baker
Journal:  Am J Hum Genet       Date:  1984-01       Impact factor: 11.025

10.  Chromosome fragility of lymphocytes from breast cancer patients in relation to epidemiologic data.

Authors:  H Ochi; S Watanabe; T Furuya; S Tsugane
Journal:  Jpn J Cancer Res       Date:  1988-09
  10 in total

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