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Literature DB >> 7115318

The effects of lactoyl-pepstatin and the pepsin inhibitor peptide on pig cathepsin D.

Abstract

Lactoyl-pepstatin (an acylated tetrapeptide) is much more readily soluble in aqueous media than the more common isovaleryl- and acetyl-pepstatins (acylated pentapeptides). However, the K1 value for inhibition of cathepsin D by lactoyl-pepstatin at pH 3.5 is approx. 10(-7) M, some two to three orders of magnitude weaker than has been obtained previously for isovaleryl- or acetyl-pepstatins. One of the peptides released during activation of pig pepsinogen is known to be an effective inhibitor of pig pepsin, but it does not alter the activity of the similar aspartic proteinase, pig cathepsin D.

Entities: Chemical Gene Species

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Year: 1982 PMID： 7115318 PMCID： PMC1158299 DOI： 10.1042/bj2030795

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

15 in total

1. Purification and properties of pepstatin hydrolase from Bacillus sphaericus.

Authors: H Tone; Y Matsushita; Y Yagi; A Tamkamatsu
Journal: J Antibiot (Tokyo) Date: 1975-12 Impact factor: 2.649

2. Interaction of human cathepsin D with the inhibitor pepstatin.

Authors: C G Knight; A J Barrett
Journal: Biochem J Date: 1976-04-01 Impact factor: 3.857

3. Inhibition of pepsin by zymogen activation fragments. Spectrum of peptides released from pepsinogen NH2 terminus and solid phase synthesis of two inhibitory peptide sequences.

Authors: B M Dunn; C Deyrup; W G Moesching; W A Gilbert; R J Nolan; M L Trach
Journal: J Biol Chem Date: 1978-10-25 Impact factor: 5.157

4. Cathepsin D: rapid isolation by affinity chromatography on haemoglobin-agarose resin.

Authors: R Smith; V Turk
Journal: Eur J Biochem Date: 1974-10-01

5. Inhibition of intracellular protein degradation by pepstatinyl, poly(L-lysine), and pepstatinyl-poly(L-lysine).

Authors: P Campbell; G I Glover; J M Gunn
Journal: Arch Biochem Biophys Date: 1980-09 Impact factor: 4.013

6. The first step in the activation of chicken pepsinogen is similar to that of prochymosin.

Authors: H Keilova; V Kostka; J Kay
Journal: Biochem J Date: 1977-12-01 Impact factor: 3.857

7. Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effects of structure on inhibition of pepsin and renin.

Authors: D H Rich; E T Sun; E Ulm
Journal: J Med Chem Date: 1980-01 Impact factor: 7.446

The effects of lactoyl-pepstatin and the pepsin inhibitor peptide on pig cathepsin D.

1. Purification and properties of pepstatin hydrolase from Bacillus sphaericus.

2. Interaction of human cathepsin D with the inhibitor pepstatin.

3. Inhibition of pepsin by zymogen activation fragments. Spectrum of peptides released from pepsinogen NH2 terminus and solid phase synthesis of two inhibitory peptide sequences.

4. Cathepsin D: rapid isolation by affinity chromatography on haemoglobin-agarose resin.

5. Inhibition of intracellular protein degradation by pepstatinyl, poly(L-lysine), and pepstatinyl-poly(L-lysine).

6. The first step in the activation of chicken pepsinogen is similar to that of prochymosin.

7. Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effects of structure on inhibition of pepsin and renin.

8. Mode of inhibition of acid proteases by pepstatin.

9. Biological activity of aspartic proteinase inhibitors related to pepstatin.

10. Binding of Streptomyces pepsin inhibitor (acetyl-pepstatin) with chymosin (Rennin).

1. Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.

2. The selectivity of action of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae).