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Literature DB >> 6432332

Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.

W A Reid, L Vongsorasak, J Svasti, M J Valler, J Kay.

Abstract

On the basis of a) kinetic data obtained with a synthetic substrate and two peptide inhibitors and b) immunological cross-reactivity, it is shown that the aspartic proteinase of human seminal fluid is a gastricsin. The source of the precursor (progastricsin) in the male genital tract is identified to be the prostate.

Entities: Gene Species

Mesh：

Substances：

Year: 1984 PMID： 6432332 DOI： 10.1007/bf00217228

Source DB: PubMed Journal: Cell Tissue Res ISSN： 0302-766X Impact factor: 5.249

11 in total

1. Immunohistochemical studies on human gastric mucosa. Procedures for routine demonstration of gastric proteins by immunoenzyme techniques.

Authors: K Wurster; W D Kuhlmann; W Rapp
Journal: Virchows Arch A Pathol Anat Histol Date: 1978-06-15

2. Cellular localization of hog pepsinogens.

Authors: W M Liebman; I M Samloff
Journal: J Histochem Cytochem Date: 1979-07 Impact factor: 2.479

3. Immunologic studies of human group I pepsinogens.

Authors: I M Samloff
Journal: J Immunol Date: 1971-04 Impact factor: 5.422

4. Cellular localization of the group II pepsinogens in human stomach and duodenum by immunofluorescence.

Authors: I M Samloff; W M Liebman
Journal: Gastroenterology Date: 1973-07 Impact factor: 22.682

5. Human prostatic gastricsinogen: the precursor of seminal fluid acid proteinase.

Authors: L Chiang; L Contreras; J Chiang; P H Ward
Journal: Arch Biochem Biophys Date: 1981-08 Impact factor: 4.013

Review 6. Gastric proteinases--structure, function, evolution and mechanism of action.

Authors: B Foltmann
Journal: Essays Biochem Date: 1981 Impact factor: 8.000

7. Immunochemical study and cellular localization of human pepsinogens during ontogenesis and in gastric cancers.

Authors: H Hirsch-Marie; F Loisillier; J P Touboul; P Burtin
Journal: Lab Invest Date: 1976-06 Impact factor: 5.662

8. The effects of lactoyl-pepstatin and the pepsin inhibitor peptide on pig cathepsin D.

Authors: J Kay; E G Afting; T Aoyagi; B M Dunn
Journal: Biochem J Date: 1982-06-01 Impact factor: 3.857

9. THE MECHANISM OF ENZYME-INHIBITOR-SUBSTRATE REACTIONS : ILLUSTRATED BY THE CHOLINESTERASE-PHYSOSTIGMINE-ACETYLCHOLINE SYSTEM.

Authors: A Goldstein
Journal: J Gen Physiol Date: 1944-07-20 Impact factor: 4.086

Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.

1. Immunohistochemical studies on human gastric mucosa. Procedures for routine demonstration of gastric proteins by immunoenzyme techniques.

2. Cellular localization of hog pepsinogens.

3. Immunologic studies of human group I pepsinogens.

4. Cellular localization of the group II pepsinogens in human stomach and duodenum by immunofluorescence.

5. Human prostatic gastricsinogen: the precursor of seminal fluid acid proteinase.

Review 6. Gastric proteinases--structure, function, evolution and mechanism of action.

7. Immunochemical study and cellular localization of human pepsinogens during ontogenesis and in gastric cancers.

8. The effects of lactoyl-pepstatin and the pepsin inhibitor peptide on pig cathepsin D.

9. THE MECHANISM OF ENZYME-INHIBITOR-SUBSTRATE REACTIONS : ILLUSTRATED BY THE CHOLINESTERASE-PHYSOSTIGMINE-ACETYLCHOLINE SYSTEM.

10. Improved purification and fluorescence changes upon activation of human seminal plasma acidic protease proenzyme.

1. Demonstration of pepsinogen C in human pancreatic islets.

2. The selectivity of action of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae).

3. Immunolocalization of cathepsin D in normal and neoplastic human tissues.

4. Gastricsin in the benign and malignant prostate.

Review 5. Pepsinogen C expression, regulation and its relationship with cancer.