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Literature DB >> 3907626

The selectivity of action of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae).

T Dreyer, M J Valler, J Kay, P Charlton, B M Dunn.

Abstract

The ability of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae) to affect the activities of a range of mammalian and microbial aspartic proteinases was examined. The inhibitor appeared to be completely selective in that only the aspartic proteinase A from yeast was inhibited to any significant extent. IA3 thus represents the first example of a totally specific, naturally occurring, aspartic-proteinase inhibitor.

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Year: 1985 PMID： 3907626 PMCID： PMC1152817 DOI： 10.1042/bj2310777

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

13 in total

1. Interaction of human cathepsin D with the inhibitor pepstatin.

Authors: C G Knight; A J Barrett
Journal: Biochem J Date: 1976-04-01 Impact factor: 3.857

2. Studies on the proteinase-A inhibitor I3A from yeast.

Authors: I Núñez de Castro; H Holzer
Journal: Hoppe Seylers Z Physiol Chem Date: 1976-05

3. Urification and characterization of macromolecular inhibitors of proteinase A from yeast.

Authors: T Saheki; Y Matsuda; H Holzer
Journal: Eur J Biochem Date: 1974-09-01

4. Pepsin inhibitors from Ascaris lumbricoides. Pepsin-inhibitor complex: stoichiometry of formation, dissociation, and stability of the complex.

Authors: G M Abu-Erreish; R J Peanasky
Journal: J Biol Chem Date: 1974-03-10 Impact factor: 5.157

5. Potent new inhibitors of human renin.

Authors: M Szelke; B Leckie; A Hallett; D M Jones; J Sueiras; B Atrash; A F Lever
Journal: Nature Date: 1982-10-07 Impact factor: 49.962

6. Effect of pepstatin on acid proteases.

Authors: T Aoyagi; S Kunimoto; H Morishima; T Takeuchi; H Umezawa
Journal: J Antibiot (Tokyo) Date: 1971-10 Impact factor: 2.649

7. The active site of aspartic proteinases.

Authors: L Pearl; T Blundell
Journal: FEBS Lett Date: 1984-08-20 Impact factor: 4.124

8. The effects of lactoyl-pepstatin and the pepsin inhibitor peptide on pig cathepsin D.

Authors: J Kay; E G Afting; T Aoyagi; B M Dunn
Journal: Biochem J Date: 1982-06-01 Impact factor: 3.857

9. Inhibition of pepsin by analogues of pepsinogen-(1-12)-peptide with substitutions in the 4-7 sequence region.

Authors: B M Dunn; M Lewitt; C Pham
Journal: Biochem J Date: 1983-02-01 Impact factor: 3.857

10. A 56,000-dalton renin-binding protein in hog kidney is an endogenous renin inhibitor.

Authors: N Ueno; H Miyazaki; S Hirose; K Murakami
Journal: J Biol Chem Date: 1981-12-10 Impact factor: 5.157

5 in total

1. Predicting functional residues of the Solanum lycopersicum aspartic protease inhibitor (SLAPI) by combining sequence and structural analysis with molecular docking.

Authors: Yasel Guerra; Pedro A Valiente; Colin Berry; Tirso Pons
Journal: J Mol Model Date: 2011-11-20 Impact factor: 1.810

5. Multi-scaled explorations of binding-induced folding of intrinsically disordered protein inhibitor IA3 to its target enzyme.

Authors: Jin Wang; Yong Wang; Xiakun Chu; Stephen J Hagen; Wei Han; Erkang Wang
Journal: PLoS Comput Biol Date: 2011-04-07 Impact factor: 4.475