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Literature DB >> 7115080

Chelation in metal intoxication. XII. Antidotal efficacy of chelating agents on acute toxicity of manganese.

Abstract

Several structurally different metal chelating agents were screened for their relative efficacy in counteracting acute manganese intoxication in mice. Polyaminocarboxylic acids with nitrogen and oxygen as metal binding sites were more effective than certain sulfhydryl chelating agents and common drugs in preventing mortality due to a lethal dose of manganese chloride. However, a few common drugs which could be used in high dosage or for longer duration in manganese intoxication without serious side effects, appear promising.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1982 PMID： 7115080 DOI： 10.1007/bf00569233

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

11 in total

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Journal: Pharmacol Rev Date: 1961-06 Impact factor: 25.468

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Authors: J Singh; S V Chandra; S K Tandon
Journal: Bull Environ Contam Toxicol Date: 1975-10 Impact factor: 2.151

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Authors: V Eybl; J Sýkora; F Mertl
Journal: Int Arch Arbeitsmed Date: 1969

7. Chelation in metal intoxication. I. In vivo effect of chelating agents on liver and testis of manganese administered rats.

Authors: S K Tandon; S V Chandra; J Singh; R Husain; P K Seth
Journal: Environ Res Date: 1975-02 Impact factor: 6.498

8. Chelation in metal intoxication. VI. Influence of PAS and CDTA on the excretion of manganese in rabbits given MnO2.

Authors: S K Tandon
Journal: Toxicology Date: 1978-04 Impact factor: 4.221

9. Removal of manganese by chelating agents from brain and liver of manganese treated rats: as in vitro and an in vivo study.

Authors: S K Tandon; J Singh
Journal: Toxicology Date: 1975-11 Impact factor: 4.221

10. Chelation in metal intoxication. IX. Influence of amino and thiol chelators on excretion of manganese in poisoned rabbits.

Authors: S Khandelwal; D N Kachru; S K Tandon
Journal: Toxicol Lett Date: 1980-08 Impact factor: 4.372

3 in total