Chelation in metal intoxication. VI. Influence of PAS and CDTA on the excretion of manganese in rabbits given MnO2.

The success of p-aminosalicyclic acid (PAS) and 1,2-cyclohexylene dinitrilotetraacetic acid (CDTA) in the mobilization of manganese from some vital organs and their subcellular fractions of manganese-intoxicated rats, led to the two compounds beng further investigated individually and in combination for their efficacy in influencing excretion of manganese in rabbits given MnO2. These chelating agents led to a higher excretion of manganese through faeces than urine. Whereas CDTA was able to enhance the excretion of manganese significantly through both routes, PAS could do so through faeces only. However, the combination did not improve upon the effect of the individual compounds.