Chelation in metal intoxication II: In vitro and in vivo effect of some compounds on brain, liver, and testis of rats treated with manganese sulphate.

Some structurally different compounds were examined for their ability to remove manganese as their chelates from brain, liver and testis and the sub-cellular fractions of brain and liver of manganese administered rats. An attempt was also made to corelate the removal of the metal with the recovery of altered activity of succinic dehydrogenase in these organs. While all the compounds were able to remove the metal significantly from in vivo brain, liver and testis, they could fully restore the enzyme activity only in brain. However, there was no significant improvement in the altered morphology of the tissues in eight days of treatment with the chelating agents.