Literature DB >> 710857

Experimental evidence for vasoactive intestinal peptide as the cause of the watery diarrhea syndrome.

I M Modlin, S R Bloom, S J Mitchell.   

Abstract

We have infused pure porcine vasoactive intestinal peptide (VIP) into 8 healthy ambulant unsedated pigs. At plasma VIP levels closely comparable to those found in the human Verner-Morrison syndrome, gross watery diarrhea and hypokalemia were produced. When the VIP infusion was discontinued the water diarrhea ceased abruptly. This study therefore provides some evidence to implicate VIP as a possible causal agent in the pathogenesis of the human watery diarrhea syndrome.

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Year:  1978        PMID： 710857

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  16 in total

1.  Simultaneous immunohistochemical demonstration of vasoactive intestinal polypeptide and its receptor in human colon.

Authors:  W Kummer
Journal:  Histochem J       Date:  1990-05

2.  Exacerbation of diarrhea after iodinated contrast agents in a patient with VIPoma.

Authors:  G S Weinstein; T M O'Dorisio; R J Joehl; B Pokorney; K L Koch
Journal:  Dig Dis Sci       Date:  1985-06       Impact factor: 3.199

3.  A pathophysiological study of the intestinal manifestations of a vasoactive intestinal peptide, calcitonin, and catecholamine-secreting tumour.

Authors:  I W Booth; T R Fenton; P J Milla; J T Harries
Journal:  Gut       Date:  1983-10       Impact factor: 23.059

4.  Vasoactive intestinal peptide concentrations and immunocytochemical studies in rectal biopsies from patients with inflammatory bowel disease.

Authors:  C O'Morain; A E Bishop; G P McGregor; A J Levi; S R Bloom; J M Polak; T J Peters
Journal:  Gut       Date:  1984-01       Impact factor: 23.059

5.  Intractable diarrhoea in a patient with vasoactive intestinal peptide-secreting neuroblastoma. Attempted control by somatostatin.

Authors:  K Tiedemann; J Pritchard; R Long; S R Bloom
Journal:  Eur J Pediatr       Date:  1981-10       Impact factor: 3.183

6.  Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine.

Authors:  M Camilleri; B T Cooper; T E Adrian; S R Bloom; V S Chadwick
Journal:  Gut       Date:  1981-01       Impact factor: 23.059

7.  Effects of bombesin, calcitonin, and enkephalin on canine jejunal water and electrolyte transport.

Authors:  G O Barbezat; P G Reasbeck
Journal:  Dig Dis Sci       Date:  1983-03       Impact factor: 3.199

8.  Primary Pancreatic Secretinoma: Further Evidence Supporting Secretin as a Diarrheogenic Hormone.

Authors:  William Y Chey; Wendy L Frankel; Sashwati Roy; Soma Datta; Chandan K Sen; Mary Dillhoff; Peter Muscarella; Konrad H Soergel; Ronald K Tompkins; Ta-Min Chang; Edward L Bradley; Edwin Christopher Ellison
Journal:  Ann Surg       Date:  2017-08       Impact factor: 12.969

9.  Peptide histidine isoleucine (PHI). A secretagogue in porcine intestine.

Authors:  A A Anagnostides; K Manolas; N D Christofides; Y Yiangou; R B Welbourn; S R Bloom; V S Chadwick
Journal:  Dig Dis Sci       Date:  1983-10       Impact factor: 3.199

10.  Watery diarrhoea with a vasoactive intestinal peptide-producing ganglioneuroblastoma.

Authors:  Y Iida; O Nose; H Kai; A Okada; T Mori; P K Lee; K Kakudo; N Yanaihara
Journal:  Arch Dis Child       Date:  1980-12       Impact factor: 3.791
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