| Literature DB >> 6257593 |
M Camilleri, B T Cooper, T E Adrian, S R Bloom, V S Chadwick.
Abstract
The effects of porcine vasoactive intestinal peptide (VIP) and bovine pancreatic polypeptide (PP) on jejunal, ileal, and colonic fluid transport were studied in the rabbit. VIP produced secretion in the small intestine (jejunum greater than ileum) but did not affect absorption in the colon. PP had no secretory effects in jejunum, ileum, or colon. The small intestinal secretion induced by VIP was not associated with raised cAMP concentrations in the mucosa; this suggests that the secretory effects of VIP in vivo are mediated by a mechanism other than stimulation of adenylate cyclase.Entities:
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Year: 1981 PMID: 6257593 PMCID: PMC1419312 DOI: 10.1136/gut.22.1.14
Source DB: PubMed Journal: Gut ISSN: 0017-5749 Impact factor: 23.059