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Literature DB >> 6118274

Intractable diarrhoea in a patient with vasoactive intestinal peptide-secreting neuroblastoma. Attempted control by somatostatin.

K Tiedemann, J Pritchard, R Long, S R Bloom.

Abstract

A 1 1/2 year old child developed profuse watery diarrhoea, shown to be due to excessive plasma vasoactive intestinal peptide (VIP) levels, whilst on treatment for metastatic neuroblastoma. Because it was unresponsive to alternative treatment, an attempt was made to control the diarrhoea with a somatostatin infusion. The attempt failed despite the fact that serum VIP levels were substantially reduced. Possible reasons for failure are discussed and the importance of plasma VIP as a marker for maturation in neuroblastoma emphasised.

Entities: Disease Gene Species

Mesh：

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Year: 1981 PMID： 6118274 DOI： 10.1007/bf00441321

Source DB: PubMed Journal: Eur J Pediatr ISSN： 0340-6199 Impact factor: 3.183

12 in total

1. Watery diarrhea syndrome in an adult with ganglioneuroma-pheochromocytoma: identification of vasoactive intestinal peptide, calcitonin, and catecholamines and assessment of their biologic activity.

Authors: D L Trump; J N Livingston; S B Baylin
Journal: Cancer Date: 1977-10 Impact factor: 6.860

Intractable diarrhoea in a patient with vasoactive intestinal peptide-secreting neuroblastoma. Attempted control by somatostatin.

1. Watery diarrhea syndrome in an adult with ganglioneuroma-pheochromocytoma: identification of vasoactive intestinal peptide, calcitonin, and catecholamines and assessment of their biologic activity.

2. Vasoactive intestinal peptide and watery-diarrhoea syndrome.

3. Vasoactive intestinal peptide secreting tumors of childhood.

4. Somatostatin treatment of insulin excess due to beta-cell adenoma in a neonate.

5. Measurement of fasting and postprandial plasma VIP in man.

6. Suppression of pancreatic endocrine tumour secretion by long-acting somatostatin analogue.

7. Watery diarrhoea and ganglioneuroma with secretion of vasoactive intestinal peptide.

8. Vasoactive intestinal peptide and its relationship to ganglion cell differentiation in neuroblastic tumors.

9. The effect of somatostatin analogs on secretion of growth, pancreatic, and gastrointestinal hormones in man.

10. Experimental evidence for vasoactive intestinal peptide as the cause of the watery diarrhea syndrome.

1. Gastroenteropancreatic endocrine tumors.

Review 2. Role of gastrointestinal hormones in neuroblastoma.

Review 3. Antidiarrheal therapy. Prospects for new agents.

4. Tumor with watery diarrhoea, hypokalaemia in a 3-year-old girl.

5. Plasma vasoactive intestinal polypeptide and other regulatory peptides in children with neurogenic tumours.