Literature DB >> 7041958

A placebo-controlled blind trial of cyclosporin-A in prevention of corneal graft rejection in rabbits.

T A Bell, D L Easty, K G McCullagh.   

Abstract

Cyclosporin-A (CyA) administered to rabbits intramuscularly in a dose of 25 mg/kg/day for 14 days following interlamellar corneal grafting had a significant effect in preventing rejection of the corneal graft (p less than 0.05), and the benefit was maintained. Rejection was attended by an initial mild inflammatory reaction and followed by a protracted intense response involving a variety of cell types, with subsequent loss of epithelium. endothelium and keratocytes, and the development of areas of stromal necrosis. CyA suppressed this rejection response.

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Year:  1982        PMID： 7041958      PMCID： PMC1039784          DOI： 10.1136/bjo.66.5.303

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN： 0007-1161            Impact factor:   4.638


  7 in total

1.  Studies of immunity with interlamellar corneal homografts in rabbits.

Authors:  P K BASU; H L ORMSBY
Journal:  Am J Ophthalmol       Date:  1957-11       Impact factor: 5.258

2.  Effects of the new anti-lymphocytic peptide cyclosporin A in animals.

Authors:  J F Borel; C Feurer; C Magnée; H Stähelin
Journal:  Immunology       Date:  1977-06       Impact factor: 7.397

3.  Induction of specific tolerance in rabbits by kidney allografting and short periods of cyclosporin-A treatment.

Authors:  C J Green; A C Allison; S Precious
Journal:  Lancet       Date:  1979-07-21       Impact factor: 79.321

4.  Cyclosporin A in patients receiving renal allografts from cadaver donors.

Authors:  R Y Calne; D J White; S Thiru; D B Evans; P McMaster; D C Dunn; G N Craddock; B D Pentlow; K Rolles
Journal:  Lancet       Date:  1978 Dec 23-30       Impact factor: 79.321

5.  Prolonged survival of pig orthotopic heart grafts treated with cyclosporin A.

Authors:  R Y Calne; D J White; K Rolles; D P Smith; B M Herbertson
Journal:  Lancet       Date:  1978-06-03       Impact factor: 79.321

6.  Extensive prolongation of rabbit kidney allograft survival after short-term cyclosporin-A treatment.

Authors:  C J Green; A C Allison
Journal:  Lancet       Date:  1978-06-03       Impact factor: 79.321

7.  Effect of cyclosporin A on the survival of corneal grafts in rabbits.

Authors:  W F Shepherd; D J Coster; T C Fook; N S Rice; B R Jones
Journal:  Br J Ophthalmol       Date:  1980-03       Impact factor: 4.638
  7 in total
  9 in total

1.  Liposome-bound cyclosporine: aqueous and vitreous level after subconjunctival injection.

Authors:  A A Alghadyan; G A Peyman; B Khoobehi; S Milner; K R Liu
Journal:  Int Ophthalmol       Date:  1988       Impact factor: 2.031

2.  Liposome-bound cyclosporine: retinal toxicity after intravitreal injection.

Authors:  A A Alghadyan; G A Peyman; B Khoobehi; K R Liu
Journal:  Int Ophthalmol       Date:  1988       Impact factor: 2.031

3.  Prevention of experimental corneal allograft rejection in rabbits using cyclosporin-collagen shields.

Authors:  K Mahlberg; R J Uusitalo; B Gebhardt; H E Kaufman
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1991       Impact factor: 3.117

4.  Prolonged survival of allogeneic corneal grafts in rabbits treated with topically applied cyclosporin A: systemic absorption and local immunosuppressive effect.

Authors:  B Foets; L Missotten; P Vanderveeren; W Goossens
Journal:  Br J Ophthalmol       Date:  1985-08       Impact factor: 4.638

5.  The effect of topical cyclosporin A on the rabbit cornea. A clinical and electron microscopic study.

Authors:  W Behrens-Baumann; S Theuring; H Brewitt
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1986       Impact factor: 3.117

6.  The use of systemic cyclosporin a in human corneal transplantation: a preliminary report.

Authors:  J C Hill
Journal:  Doc Ophthalmol       Date:  1986-05-15       Impact factor: 2.379

7.  Penetration of 2% cyclosporin eyedrops into human aqueous humour.

Authors:  M Diaz-Llopis; J L Menezo
Journal:  Br J Ophthalmol       Date:  1989-08       Impact factor: 4.638

8.  Ciclosporin concentration in the rabbit aqueous humor and cornea following subconjunctival administration. Importance of anatomical site of injection.

Authors:  W Behrens-Baumann; S Theuring; B Frey; F Frey; H Sostmann; J Bircher
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1986       Impact factor: 3.117

Review 9.  Cyclosporine: immunology, toxicity and pharmacology in experimental animals.

Authors:  A W Thomson; P H Whiting; J G Simpson
Journal:  Agents Actions       Date:  1984-10
  9 in total

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